HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	30024968, 32900848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 236
+	Hs
		887790 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		444700 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		837596 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		670443 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887848 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887789 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		326032 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48