Interactor 1: IL4 (P05112)
Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)
Gene: IL4
Interactor 2: IL4RA (P24394)
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
Gene: IL4R
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11786020, 7721786, 9874253, 10219247, 8639787, 8266078, 2307934, 2278997, 18243101, 23597562 |
| Identification Methods | x-ray crystallography, coimmunoprecipitation, cross-linking study, protein cross-linking with a bifunctional reagent, anti tag coimmunoprecipitation, saturation binding, isothermal titration calorimetry, anti bait coimmunoprecipitation, scintillation proximity assay |
| Interaction Type | association, direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL4~IL4Ra_N |
| Common GO terms | GO:0005576 - extracellular region GO:0006955 - immune response GO:0035771 - interleukin-4-mediated signaling pathway GO:0043306 - positive regulation of mast cell degranulation GO:0045064 - T-helper 2 cell differentiation and 2 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
