HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20348541
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1217
+	Hs
		396117 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		397034 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC4_HUMAN (1-1206): 2.28e-77: 281: 16.77
+	Hs
		333914 ESR1_HUMAN (1-595): 0: 599: 100.00		SMC2_HUMAN (1-1217): 2.53e-73: 268: 18.97
+	Hs
		1367611 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Hs
		834095 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Hs
		1130131 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		395408 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH6_HUMAN (546-1109): 2.76e-17: 90.1: 10.88
+	Hs
		1367382 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SMC4_HUMAN (1-1206): 2.28e-77: 281: 16.77
+	Hs
		334068 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SMC2_HUMAN (1-1217): 2.53e-73: 268: 18.97
+	Hs
		404057 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		520461 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Hs
		1367703 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		MYH4_HUMAN (354-1101): 2.04e-24: 113: 9.34
+	Hs
		556943 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		MYH7_HUMAN (627-1126): 2.95e-15: 83.6: 13.49
+	Hs
		520043 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Hs
		404534 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		MYH2_HUMAN (549-1104): 4.41e-16: 86.3: 11.07