HitPredict

Interactor 1: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Interactor 2: SH2B1 (Q91ZM2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
Gene: SH2B1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10679268
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030032 - lamellipodium assembly GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 979 Mm			1 756
+	Hs
		499273 KIT_HUMAN (1-978): 0: 795: 79.55		TENS3_HUMAN (7-744): 1.02e-84: 295: 11.87
+	Hs
		499272 KIT_HUMAN (1-978): 0: 795: 79.55		TENS2_HUMAN (77-743): 3.54e-82: 288: 12.88
+	Hs
		499246 KIT_HUMAN (1-978): 0: 795: 79.55		KSYK_HUMAN (349-716): 2.97e-59: 213: 14.70
+	Hs
		499242 KIT_HUMAN (1-978): 0: 795: 79.55		TEC_HUMAN (291-644): 7.63e-59: 212: 14.80
+	Mm
		403538 KIT_MOUSE (1-979): 0: 823: 96.85		MATK_MOUSE (432-636): 2.62e-47: 177: 19.91
+	Hs
		499237 KIT_HUMAN (1-978): 0: 795: 79.55		SHC1_HUMAN (89-625): 1.88e-56: 204: 19.06
+	Hs
		499274 KIT_HUMAN (1-978): 0: 795: 79.55		SHC4_HUMAN (328-631): 5.72e-55: 201: 19.81
+	Hs
		411962 KIT_HUMAN (1-978): 0: 795: 79.55		FYN_HUMAN (374-735): 1.77e-52: 193: 14.36
+	Hs
		411567 KIT_HUMAN (1-978): 0: 795: 79.55		LCK_HUMAN (395-700): 4.11e-52: 191: 15.66
+	Hs
		499222 KIT_HUMAN (1-978): 0: 795: 79.55		SRC_HUMAN (394-645): 1.63e-51: 190: 13.43
+	Hs
		433226 KIT_HUMAN (1-978): 0: 795: 79.55		YES_HUMAN (388-645): 4.77e-51: 189: 14.18
+	Hs
		442765 KIT_HUMAN (1-978): 0: 795: 79.55		HCK_HUMAN (372-701): 1.09e-50: 187: 14.58
+	Hs
		499256 KIT_HUMAN (1-978): 0: 795: 79.55		SHC2_HUMAN (328-628): 4.38e-46: 175: 21.10
+	Mm
		140055 KIT_MOUSE (1-979): 0: 823: 96.85		P85B_MOUSE (335-651): 7.71e-35: 143: 15.00
+	Hs
		499243 KIT_HUMAN (1-978): 0: 795: 79.55		TXK_HUMAN (411-625): 6.53e-45: 171: 16.30
+	Hs
		499241 KIT_HUMAN (1-978): 0: 795: 79.55		MATK_HUMAN (432-641): 2.55e-43: 166: 19.44
+	Hs
		129178 KIT_HUMAN (1-978): 0: 795: 79.55		P85B_HUMAN (307-651): 5.64e-35: 144: 15.78
+	Hs
		499279 KIT_HUMAN (1-978): 0: 795: 79.55		SHC3_HUMAN (403-616): 4.49e-26: 115: 19.62
+	Mm
		403541 KIT_MOUSE (1-979): 0: 823: 96.85		GRB2_MOUSE (517-609): 7.64e-15: 76.2: 22.58
+	Hs
		499253 KIT_HUMAN (1-978): 0: 795: 79.55		GRB2_HUMAN (517-609): 7.64e-15: 76.2: 22.58