Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 2033070, 16271887, 29512653, 12456798, 16957736, 18278056, 23302862, 26853939
Identification Methods pull down, enzymatic study, x-ray crystallography, protein kinase assay, molecular sieving
Interaction Type direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3, Furin-like~Furin-like, Furin-like~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain
Common GO terms GO:0001540 - amyloid-beta binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0002092 - positive regulation of receptor internalization
GO:0003007 - heart morphogenesis
GO:0004713 - protein tyrosine kinase activity
and 68 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1382
Hs

1 1382
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Last updated: 15 Jul 2024