HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	10803466
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 532
+	Hs
		411383 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Rn
		292434 T2CB11_RAT (1-1382): 0: 1538: 94.87		GRB14_RAT (12-532): 0: 601: 46.96
+	Rn
		292431 INSR_RAT (1-1382): 0: 1527: 94.44		GRB14_RAT (12-532): 0: 601: 46.96
+	Hs
		411376 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Hs
		435642 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Hs
		435632 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		411523 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		411292 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Rn
		499158 INSR_RAT (1-1382): 0: 1527: 94.44		PLCG1_RAT (200-532): 1.02e-49: 186: 14.97
+	Mm
		403410 INSR_MOUSE (1-1382): 0: 1509: 94.36		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Hs
		411329 INSR_HUMAN (1-1382): 0: 1530: 100.00		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Mm
		546274 INSR_MOUSE (1-1382): 0: 1509: 94.36		GRB10_MOUSE (2-77): 1.15e-12: 72.6: 33.33
+	Hs
		435801 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		433523 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		435518 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		435573 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Hs
		435570 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Hs
		435602 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89