HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 223
+	Hs
		304907 INSR_HUMAN (1-1382): 0: 1530: 100.00		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		411454 INSR_HUMAN (1-1382): 0: 1530: 100.00		SSH1_HUMAN (10-201): 8.62e-56: 192: 28.13
+	Hs
		411444 INSR_HUMAN (1-1382): 0: 1530: 100.00		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		411449 INSR_HUMAN (1-1382): 0: 1530: 100.00		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		435704 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		537762 INSRR_HUMAN (13-1341): 0: 1293: 51.12		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		304908 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		435706 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SSH1_HUMAN (10-201): 8.62e-56: 192: 28.13
+	Hs
		435757 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS15_HUMAN (32-198): 8.37e-58: 186: 33.53
+	Hs
		435698 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		435671 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS29_HUMAN (22-174): 2.63e-56: 180: 30.77
+	Hs
		435748 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS26_HUMAN (27-176): 1.44e-56: 180: 30.46
+	Hs
		435703 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		435762 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95
+	Hs
		665415 EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		1072561 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		872488 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95
+	Hs
		665410 EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		1072555 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		665430 EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95