Protein: P5CR2
Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)

Gene: P5CR2, PYCR2
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q96C36

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0034599 - cellular response to oxidative stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733974

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

4

14

High-throughput

0.895

High

1199934

P5CR3
Pyrroline-5-carboxylate reductase 3

3

14

High-throughput

0.861

High

1308649

AHNK2
Protein AHNAK2

3

1

High-throughput

0.667

High

1385539

NUDT5
ADP-sugar pyrophosphatase

3

1

High-throughput

0.667

High

1311953

SKA3
Spindle and kinetochore-associated protein 3

3

0

High-throughput

0.638

High

1384504

SKA1
SKA complex subunit 1

3

0

High-throughput

0.638

High

1093027

CDC16
Cell division cycle protein 16 homolog

2

4

High-throughput

0.628

High

1385535

CDC23
Cell division cycle protein 23 homolog

2

4

High-throughput

0.628

High

1385483

P5CR2
Pyrroline-5-carboxylate reductase 2

1

14

High-throughput

0.618

High

471170

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

1

High-throughput

0.611

High

1123367

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

1142620

PDK1
[Pyruvate dehydrogenase

2

4

High-throughput

0.611

High

1310295

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

2

High-throughput

0.611

High

1215486

CE162
Centrosomal protein of 162 kDa

2

2

High-throughput

0.588

High

123924

MYO1F
Unconventional myosin-If

2

0

High-throughput

0.585

High

934976

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.585

High

279852

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

532842

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.584

High

560042

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

1

High-throughput

0.584

High

1087484

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

1162470

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

711394

SHC1
SHC-transforming protein 1

2

2

High-throughput

0.571

High

988598

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

High-throughput

0.571

High

1135913

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

7

Small-scale

0.571

High

1327777

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.571

High

1385504

TR61B
tRNA

2

1

High-throughput

0.571

High

326764

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.558

High

900080

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

900451

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.541

High

127715

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.536

High

540068

BCR
Breakpoint cluster region protein

1

3

High-throughput

0.536

High

718605

CDC27
Cell division cycle protein 27 homolog

1

4

High-throughput

0.536

High

729391

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

4

High-throughput

0.536

High

1068280

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.536

High

1100948

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

1113941

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1160950

PDK4
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

1228514

TENS3
Tensin-3

1

1

High-throughput

0.536

High

1385486

APC16
Anaphase-promoting complex subunit 16

1

1

High-throughput

0.536

High

1385491

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

1385507

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

1385510

5NT3A
Cytosolic 5'-nucleotidase 3A

1

1

High-throughput

0.536

High

1385536

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.536

High

1385537

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.536

High

1257030

SYDE1
Rho GTPase-activating protein SYDE1

2

5

High-throughput

0.521

High

425944

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

483180

CLCA
Clathrin light chain A

1

0

High-throughput

0.513

High

484611

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

571629

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

601802

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

625548

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

788133

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

943293

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.513

High

1005708

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.513

High

1163126

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

260927

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.489

High

619887

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.489

High

1153300

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.489

High

422834

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

61574

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

66255

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

183695

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

216774

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

282032

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287344

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

296278

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

302604

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

348648

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

350942

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

361650

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

404311

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

412410

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

519187

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

731529

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

786204

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

801447

HSPA9
Stress-70 protein, mitochondrial

1

3

High-throughput

0.479

High

828884

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

841862

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851977

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856330

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

882811

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

1015665

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1024128

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1035835

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1048625

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1058187

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1062836

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

1067588

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

1083692

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090488

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1107092

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1117797

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1149605

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1207092

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

1234477

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1240312

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

1241322

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.479

High

1271488

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

1272954

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

1316237

DOCK3
Dedicator of cytokinesis protein 3

1

2

High-throughput

0.479

High

1334743

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1337208

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

1339647

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1364507

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1366982

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1380072

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1381101

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

5

High-throughput

0.479

High

1381661

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

1383533

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

1384842

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1385484

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

1385485

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

2

High-throughput

0.479

High

1385487

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1385488

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1385490

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1385492

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

1385493

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.479

High

1385494

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

1385496

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1385498

EFGM
Elongation factor G, mitochondrial

1

5

High-throughput

0.479

High

1385499

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.479

High

1385500

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

1385501

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

1385502

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1385505

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1385506

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1385508

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1385509

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

1385512

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1385513

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1385514

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

1385515

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1385517

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1385518

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1385519

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1385523

NGRN
Neugrin

1

1

High-throughput

0.479

High

1385524

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

1385525

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1385526

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

1385527

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

1385528

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

1385530

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

1385531

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1385532

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

1385533

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1385534

FKBPL
FK506-binding protein-like

1

4

High-throughput

0.479

High

1385541

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

1385543

DJC15
DnaJ homolog subfamily C member 15

1

2

High-throughput

0.479

High

1385497

CIC
Protein capicua homolog

1

2

High-throughput

0.464

High

141608

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.458

High

324308

ARHGF
Rho guanine nucleotide exchange factor 15

1

0

High-throughput

0.458

High

363693

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

659550

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

767296

MERL
Merlin

1

0

High-throughput

0.458

High

831209

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1045621

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1270598

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1347629

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.458

High

1385489

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1385503

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1385521

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1098

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

1227219

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

1385544

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

294144

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

315860

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

372791

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

650342

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

711926

LTK
Leukocyte tyrosine kinase receptor

1

4

High-throughput

0.437

High

851633

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

1100210

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.437

High

1121298

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

1129689

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.437

High

1155643

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

1215758

RC3H1
Roquin-1

1

1

Small-scale

0.437

High

1254982

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1276615

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1290637

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

1310864

LMTK2
Serine/threonine-protein kinase LMTK2

1

4

High-throughput

0.437

High

1314351

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.437

High

1385495

LMTK3
Serine/threonine-protein kinase LMTK3

1

5

High-throughput

0.437

High

1385516

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1385520

RC3H2
Roquin-2

1

4

Small-scale

0.437

High

1385522

DNJC4
DnaJ homolog subfamily C member 4

1

5

High-throughput

0.437

High

1385538

KCND3
A-type voltage-gated potassium channel KCND3

1

1

Small-scale

0.437

High

613428

VINC
Vinculin

1

0

High-throughput

0.426

High

754080

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

1365567

MY18A
Unconventional myosin-XVIIIa

3

0

High-throughput

0.347

High

326971

UBE4B
Ubiquitin conjugation factor E4 B

1

0

Small-scale

0.292

High

1325889

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1385511

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.279

Low

555515

SKIL
Ski-like protein

1

0

High-throughput

0.265

Low

710742

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

1088498

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.249

Low

1149956

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1312163

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.249

Low

1385529

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

1385542

NGN3
Neurogenin-3

1

0

Small-scale

0.249

Low

848542

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.232

Low

1214169

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1385540

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025