Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CD4 (P06332)
T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Gene: CD4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 0.60 0.670

The method score is based on:

Property Details
Experiments 10358158, 7664803, 7486703, 24034254
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005102 - signaling receptor binding
GO:0007166 - cell surface receptor signaling pathway
GO:0030217 - T cell differentiation
GO:0045121 - membrane raft
GO:0050870 - positive regulation of T cell activation
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 509
Mm

1 457
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024