Protein: TPR
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)

Gene: TPR
Organism: Homo sapiens
Interactions: 197
UniProt ID: P12270

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

552774

NU153
Nuclear pore complex protein Nup153

4

20

Small-scale

0.703

High

552829

ZC3C1
Zinc finger C3HC-type protein 1

4

1

Small-scale

0.692

High

385403

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

17

High-throughput

0.672

High

552894

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

3

18

Small-scale

0.665

High

552779

NU107
Nuclear pore complex protein Nup107

3

5

Small-scale

0.656

High

552738

TPR
Nucleoprotein TPR

3

19

High-throughput

0.640

High

552817

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

10

Small-scale

0.624

High

552800

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

1

Small-scale

0.611

High

552756

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.602

High

552780

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

552862

ADCYA
Adenylate cyclase type 10

2

1

High-throughput

0.601

High

552777

NUP98
Nuclear pore complex protein Nup98-Nup96

2

20

Small-scale

0.595

High

552770

NPY2R
Neuropeptide Y receptor type 2

3

1

High-throughput

0.593

High

259364

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

345310

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

15

High-throughput

0.584

High

371038

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

446596

NPM
Nucleophosmin

2

6

High-throughput

0.584

High

552765

BRCA1
Breast cancer type 1 susceptibility protein

2

20

High-throughput

0.584

High

552768

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

552844

COP1
E3 ubiquitin-protein ligase COP1

2

20

Small-scale

0.584

High

217765

TGON2
Trans-Golgi network integral membrane protein 2

2

15

High-throughput

0.571

High

552749

RAB5A
Ras-related protein Rab-5A

2

9

High-throughput

0.571

High

552754

CALX
Calnexin

2

6

High-throughput

0.571

High

552775

CDK7
Cyclin-dependent kinase 7

2

20

High-throughput

0.571

High

552792

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

High-throughput

0.571

High

552841

DOCK8
Dedicator of cytokinesis protein 8

2

4

High-throughput

0.571

High

425874

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

2

2

High-throughput

0.549

High

552752

APC
Adenomatous polyposis coli protein

1

19

High-throughput

0.541

High

552896

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

6

High-throughput

0.541

High

351369

CBX7
Chromobox protein homolog 7

1

16

High-throughput

0.536

High

361088

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

470828

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

6

High-throughput

0.536

High

552740

CFTR
Cystic fibrosis transmembrane conductance regulator

1

17

High-throughput

0.536

High

552757

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

10

High-throughput

0.536

High

552771

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.536

High

552789

FOXK2
Forkhead box protein K2

1

10

High-throughput

0.536

High

552798

ILF3
Interleukin enhancer-binding factor 3

1

17

High-throughput

0.536

High

552821

ULK3
Serine/threonine-protein kinase ULK3

1

6

High-throughput

0.536

High

552837

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.536

High

552847

DUS19
Dual specificity protein phosphatase 19

1

9

High-throughput

0.536

High

552848

STYX
Serine/threonine/tyrosine-interacting protein

1

9

Small-scale

0.536

High

552864

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

552891

HDAC9
Histone deacetylase 9

1

20

High-throughput

0.536

High

541797

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.515

High

552767

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

11

High-throughput

0.515

High

552822

NFXL1
NF-X1-type zinc finger protein NFXL1

1

1

High-throughput

0.515

High

552846

ZN721
Zinc finger protein 721

1

2

High-throughput

0.515

High

552849

PHIP
PH-interacting protein

1

20

High-throughput

0.515

High

552865

MNT
Max-binding protein MNT

1

20

High-throughput

0.515

High

552830

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.513

High

443145

CDK1
Cyclin-dependent kinase 1

1

19

Small-scale

0.501

High

552745

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

16

Small-scale

0.501

High

552794

ERCC6
DNA excision repair protein ERCC-6

1

20

High-throughput

0.501

High

552855

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

20

High-throughput

0.501

High

302351

RNF8
E3 ubiquitin-protein ligase RNF8

1

17

Small-scale

0.500

High

552816

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.493

High

388968

FINC
Fibronectin

1

7

High-throughput

0.489

High

552759

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

552769

CAPZB
F-actin-capping protein subunit beta

1

6

High-throughput

0.489

High

552783

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.489

High

552797

CALD1
Caldesmon

1

17

High-throughput

0.489

High

552868

REEP2
Receptor expression-enhancing protein 2

1

1

High-throughput

0.489

High

552869

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.489

High

354889

CHK2
Serine/threonine-protein kinase Chk2

1

17

Small-scale

0.484

High

552793

MECOM
Histone-lysine N-methyltransferase MECOM

1

10

High-throughput

0.481

High

137177

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.479

High

172439

XPO1
Exportin-1

1

10

Small-scale

0.479

High

222674

PRC1
Protein regulator of cytokinesis 1

1

17

High-throughput

0.479

High

238368

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.479

High

239297

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

16

High-throughput

0.479

High

240610

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.479

High

246413

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

247222

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

14

High-throughput

0.479

High

247638

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

271859

OBSL1
Obscurin-like protein 1

1

16

High-throughput

0.479

High

285056

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

355418

NSD2
Histone-lysine N-methyltransferase NSD2

1

18

Small-scale

0.479

High

370530

FOS
Protein c-Fos

1

7

High-throughput

0.479

High

405735

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

411270

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

459423

PROF1
Profilin-1

1

4

Small-scale

0.479

High

519695

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

552739

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

552742

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

552746

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

552748

RO52
E3 ubiquitin-protein ligase TRIM21

1

10

High-throughput

0.479

High

552753

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

552755

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.479

High

552760

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.479

High

552761

MERL
Merlin

1

19

High-throughput

0.479

High

552762

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

552763

NU214
Nuclear pore complex protein Nup214

1

16

Small-scale

0.479

High

552764

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

552766

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

552773

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.479

High

552776

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.479

High

552778

HDAC4
Histone deacetylase 4

1

20

High-throughput

0.479

High

552781

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

552782

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

552784

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

552785

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

552786

H31
Histone H3.1

1

15

High-throughput

0.479

High

552787

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

552790

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

552795

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

552796

KPCZ
Protein kinase C zeta type

1

10

High-throughput

0.479

High

552799

FOXC1
Forkhead box protein C1

1

10

High-throughput

0.479

High

552801

BIRC3
Baculoviral IAP repeat-containing protein 3

1

11

High-throughput

0.479

High

552802

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

552803

CUL4A
Cullin-4A

1

18

High-throughput

0.479

High

552804

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

552806

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

552807

CUL7
Cullin-7

1

11

High-throughput

0.479

High

552809

PAF15
PCNA-associated factor

1

1

Small-scale

0.479

High

552810

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

552811

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

10

High-throughput

0.479

High

552812

EEA1
Early endosome antigen 1

1

19

High-throughput

0.479

High

552814

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

552818

RIF1
Telomere-associated protein RIF1

1

16

High-throughput

0.479

High

552819

VIR
Protein virilizer homolog

1

6

High-throughput

0.479

High

552823

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

552824

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

552825

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

552826

SLN11
Schlafen family member 11

1

5

High-throughput

0.479

High

552827

NAA40
N-alpha-acetyltransferase 40

1

6

High-throughput

0.479

High

552833

SMC5
Structural maintenance of chromosomes protein 5

1

18

High-throughput

0.479

High

552835

NUP93
Nuclear pore complex protein Nup93

1

4

Small-scale

0.479

High

552845

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

552850

TITIN
Titin

1

20

High-throughput

0.479

High

552852

TOPB1
DNA topoisomerase 2-binding protein 1

1

15

High-throughput

0.479

High

552853

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

12

High-throughput

0.479

High

552854

NU205
Nuclear pore complex protein Nup205

1

5

Small-scale

0.479

High

552856

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

552857

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

552861

NSUN5
28S rRNA

1

3

High-throughput

0.479

High

552866

NECD
Necdin

1

14

High-throughput

0.479

High

552867

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

552871

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

552872

ACE2
Angiotensin-converting enzyme 2

1

9

High-throughput

0.479

High

552874

REN3B
Regulator of nonsense transcripts 3B

1

4

High-throughput

0.479

High

552877

CCDC8
Coiled-coil domain-containing protein 8

1

7

High-throughput

0.479

High

552878

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.479

High

552880

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

552882

KAT8
Histone acetyltransferase KAT8

1

5

Small-scale

0.479

High

552883

ANLN
Anillin

1

11

High-throughput

0.479

High

552884

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

552887

PD1L1
Programmed cell death 1 ligand 1

1

9

High-throughput

0.479

High

552888

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

552889

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.479

High

552890

RCOR1
REST corepressor 1

1

10

High-throughput

0.479

High

552892

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.479

High

552893

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.479

High

552895

NCOA3
Nuclear receptor coactivator 3

1

9

Small-scale

0.479

High

552859

MRP9
ATP-binding cassette sub-family C member 12

1

3

High-throughput

0.470

High

552743

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

552758

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.458

High

552772

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

552808

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

552832

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.458

High

552843

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

552885

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

552813

SF01
Splicing factor 1

1

3

High-throughput

0.457

High

552842

NUP37
Nucleoporin Nup37

1

20

Small-scale

0.457

High

410564

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.445

High

429210

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

552791

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

552820

NCLX
Mitochondrial sodium/calcium exchanger protein

1

3

High-throughput

0.445

High

552831

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.445

High

552875

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

156897

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.437

High

552741

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

552750

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

7

High-throughput

0.437

High

552805

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

552851

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.437

High

552858

S2544
Solute carrier family 25 member 44

1

5

High-throughput

0.437

High

552870

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

552873

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.437

High

552886

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

6

High-throughput

0.437

High

133427

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.426

High

552828

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

62445

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

552747

VCAM1
Vascular cell adhesion protein 1

1

9

High-throughput

0.407

High

552751

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.407

High

552836

SVOPL
Putative transporter SVOPL

1

1

High-throughput

0.407

High

552840

S35G3
Solute carrier family 35 member G3

1

1

High-throughput

0.407

High

552876

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

3

High-throughput

0.407

High

552879

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.407

High

552788

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.391

High

552838

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

552744

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.269

Low

552839

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

552863

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

552815

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

552834

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low

552860

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

552881

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025