HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SH22A (Q9QXK9)
SH2 domain-containing protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk-binding protein) (Ribp)
Gene: Sh2d2a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.80	0.584

Property	Details
Experiments	10553045
Identification Methods	two hybrid, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 509 Mm			1 374
+	Hs
		411870 LCK_HUMAN (1-509): 0: 634: 96.86		SH22A_HUMAN (1-354): 2.26e-86: 268: 64.62
+	Hs
		411552 LCK_HUMAN (1-509): 0: 634: 96.86		YES_HUMAN (8-300): 2.54e-77: 249: 17.81
+	Hs
		411545 LCK_HUMAN (1-509): 0: 634: 96.86		FYN_HUMAN (59-300): 1.89e-73: 239: 17.87
+	Hs
		411573 LCK_HUMAN (1-509): 0: 634: 96.86		SRC_HUMAN (59-300): 1.64e-69: 229: 19.01
+	Hs
		411544 LCK_HUMAN (1-509): 0: 634: 96.86		LCK_HUMAN (29-300): 3.6e-66: 219: 17.41
+	Hs
		411559 LCK_HUMAN (1-509): 0: 634: 96.86		HCK_HUMAN (29-300): 2.27e-64: 215: 15.93
+	Hs
		411553 LCK_HUMAN (1-509): 0: 634: 96.86		LYN_HUMAN (23-316): 1.24e-61: 207: 16.09
+	Hs
		411648 LCK_HUMAN (1-509): 0: 634: 96.86		BLK_HUMAN (59-300): 1.8e-58: 199: 16.79
+	Hs
		442772 HCK_HUMAN (1-509): 0: 591: 65.63		SRC_HUMAN (59-300): 1.64e-69: 229: 19.01
+	Hs
		442759 HCK_HUMAN (1-509): 0: 591: 65.63		HCK_HUMAN (29-300): 2.27e-64: 215: 15.93
+	Mm
		435875 HCK_MOUSE (1-509): 0: 592: 64.44		HCK_MOUSE (29-300): 3.37e-63: 212: 15.73
+	Hs
		433530 HCK_HUMAN (1-509): 0: 591: 65.63		LYN_HUMAN (23-316): 1.24e-61: 207: 16.09
+	Hs
		442813 HCK_HUMAN (1-509): 0: 591: 65.63		BTK_HUMAN (6-300): 7.8e-57: 198: 13.46
+	Mm
		411920 LCK_MOUSE (1-509): 0: 638: 100.00		ZAP70_MOUSE (93-303): 6.3e-21: 96.1: 19.25
+	Hs
		411632 LCK_HUMAN (1-509): 0: 634: 96.86		ZAP70_HUMAN (84-303): 1.24e-20: 95.3: 19.56
+	Hs
		411633 LCK_HUMAN (1-509): 0: 634: 96.86		KSYK_HUMAN (115-211): 6.94e-17: 84.2: 27.00
+	Hs
		442789 HCK_HUMAN (1-509): 0: 591: 65.63		ABL2_HUMAN (95-231): 4.35e-17: 84.9: 22.60
+	Hs
		337307 FYN_HUMAN (1-507): 0: 591: 54.03		ABL1_HUMAN (95-216): 6.01e-17: 84.6: 23.66
+	Hs
		337315 HCK_HUMAN (1-509): 0: 591: 65.63		ABL1_HUMAN (95-216): 6.01e-17: 84.6: 23.66