HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 551
+	Hs
		412256 NTRK1_HUMAN (1-796): 0: 624: 100.00		CPSF7_HUMAN (1-525): 2.62e-45: 168: 40.63
+	Hs
		411606 NTRK1_HUMAN (1-796): 0: 624: 100.00		SMCA4_HUMAN (126-551): 4.41e-41: 161: 16.18
+	Hs
		323818 NTRK1_HUMAN (1-796): 0: 624: 100.00		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Hs
		411265 NTRK1_HUMAN (1-796): 0: 624: 100.00		PABP1_HUMAN (81-480): 2.69e-24: 109: 12.35
+	Hs
		412051 NTRK1_HUMAN (1-796): 0: 624: 100.00		TGO1_HUMAN (138-380): 8.31e-13: 73.8: 25.18
+	Hs
		319083 NTRK1_HUMAN (1-796): 0: 624: 100.00		SC24D_HUMAN (131-353): 1.99e-11: 68.8: 21.49
+	Hs
		411865 NTRK1_HUMAN (1-796): 0: 624: 100.00		PABP4_HUMAN (74-172): 3.37e-10: 64.9: 17.00
+	Hs
		411641 NTRK1_HUMAN (1-796): 0: 624: 100.00		SC24C_HUMAN (246-440): 4.68e-10: 64.5: 17.81
+	Hs
		412719 NTRK1_HUMAN (1-796): 0: 624: 100.00		OGFR_HUMAN (170-417): 4.42e-09: 61.1: 21.76
+	Hs
		323827 FGFR1_HUMAN (195-794): 0: 544: 26.34		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Hs
		323876 NTRK3_HUMAN (36-796): 2.7e-175: 527: 49.37		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Hs
		323836 FGFR4_HUMAN (140-795): 1.88e-172: 518: 26.47		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Hs
		541533 FGFR1_HUMAN (195-794): 0: 544: 26.34		TGO1_HUMAN (138-380): 8.31e-13: 73.8: 25.18
+	Hs
		323821 RET_HUMAN (391-794): 4.65e-114: 374: 30.44		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Hs
		323822 IGF1R_HUMAN (493-777): 7e-71: 255: 42.61		SC31A_HUMAN (127-488): 9.44e-27: 117: 13.02
+	Rn
		108114 INSR_RAT (493-777): 7.34e-66: 241: 41.95		G3V699_RAT (120-488): 3.09e-23: 106: 15.14
+	Rn
		93206 INSR_RAT (493-777): 7.34e-66: 241: 41.95		D4A233_RAT (81-386): 5.17e-19: 92.3: 13.19
+	Hs
		465540 IGF1R_HUMAN (493-777): 7e-71: 255: 42.61		TGO1_HUMAN (138-380): 8.31e-13: 73.8: 25.18
+	Hs
		1034255 ROR2_HUMAN (515-783): 2.81e-66: 239: 43.91		TGO1_HUMAN (138-380): 8.31e-13: 73.8: 25.18
+	Hs
		319116 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		SC24D_HUMAN (131-353): 1.99e-11: 68.8: 21.49