HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9488700
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 591
+	Hs
		442793 HCK_HUMAN (1-509): 0: 602: 65.04		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		412085 FYN_HUMAN (30-507): 0: 586: 59.01		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		522857 SRC_HUMAN (20-507): 0: 586: 55.00		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		433646 LYN_HUMAN (1-509): 0: 582: 62.72		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		433288 YES_HUMAN (26-507): 0: 581: 58.06		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Mm
		403454 SRC_MOUSE (28-507): 0: 583: 57.05		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		823358 BLK_HUMAN (1-509): 0: 557: 59.35		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		337395 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Mm
		337635 ABL1_MOUSE (49-502): 5.34e-171: 513: 42.21		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		789046 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		788979 TEC_HUMAN (7-503): 2.17e-169: 494: 32.56		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		238957 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37
+	Hs
		442845 HCK_HUMAN (1-509): 0: 602: 65.04		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		111447 J3QRU1_HUMAN (26-507): 0: 581: 58.06		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		433484 YES_HUMAN (26-507): 0: 581: 58.06		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		442827 HCK_HUMAN (1-509): 0: 602: 65.04		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		254384 SRC_HUMAN (20-507): 0: 586: 55.00		LDB3_HUMAN (474-590): 4.47e-13: 74.3: 33.33
+	Ce
		107567 SRC2_CAEEL (35-507): 0: 526: 47.71		G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00
+	Ce
		106629 SRC1_CAEEL (1-508): 8.64e-179: 514: 44.84		G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00
+	Hs
		150505 LYN_HUMAN (1-509): 0: 582: 62.72		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32