HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	7589480, 17164290, 11741599, 19807924
Identification Methods	pull down, unspecified method, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 281
+	Hs
		522855 SRC_HUMAN (1-537): 0: 598: 68.21		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		433285 YES_HUMAN (1-537): 0: 591: 71.61		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		454807 FGR_HUMAN (1-536): 0: 581: 69.82		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		411638 LCK_HUMAN (40-535): 0: 551: 57.60		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		442792 HCK_HUMAN (1-535): 0: 548: 56.64		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		433642 LYN_HUMAN (1-535): 0: 535: 54.48		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		352441 FYN_HUMAN (1-537): 0: 643: 100.00		TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46
+	Hs
		815674 ITK_HUMAN (4-526): 5.88e-165: 483: 31.90		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		788978 TEC_HUMAN (5-529): 6.12e-163: 478: 34.89		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		815673 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00
+	Hs
		155678 SRC_HUMAN (1-537): 0: 598: 68.21		TNF11_HUMAN (138-281): 1.95e-54: 180: 23.57
+	Hs
		352447 LYN_HUMAN (1-535): 0: 535: 54.48		TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46