HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	28514442, 31980649, 33961781, 32707033, unassigned2173, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0097110 - scaffold protein binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 378
+	Hs
		523006 SRC_HUMAN (1-537): 0: 598: 68.21		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433368 YES_HUMAN (1-537): 0: 591: 71.61		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		454835 FGR_HUMAN (1-536): 0: 581: 69.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411738 LCK_HUMAN (40-535): 0: 551: 57.60		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		442838 HCK_HUMAN (1-535): 0: 548: 56.64		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433785 LYN_HUMAN (1-535): 0: 535: 54.48		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		789071 ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		846474 BLK_HUMAN (28-532): 2.42e-179: 515: 56.72		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		996564 ITK_HUMAN (4-526): 5.88e-165: 483: 31.90		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082800 Q573B4_HUMAN (6-535): 1.73e-161: 470: 46.99		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		986378 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082984 SRMS_HUMAN (50-528): 3.37e-152: 446: 39.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1046404 PTK6_HUMAN (83-529): 4.09e-152: 444: 42.92		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00