Protein: I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)

Gene: I2BPL, IRF2BPL
Organism: Homo sapiens
Interactions: 43
UniProt ID: Q9H1B7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571635

IRF2
Interferon regulatory factor 2

4

6

High-throughput

0.704

High

584144

FOSL2
Fos-related antigen 2

4

9

High-throughput

0.691

High

1121016

VGLL4
Transcription cofactor vestigial-like protein 4

4

2

High-throughput

0.691

High

1306957

I2BP1
Interferon regulatory factor 2-binding protein 1

4

7

Small-scale

0.691

High

1279305

I2BP2
Interferon regulatory factor 2-binding protein 2

3

13

Small-scale

0.640

High

520365

ANDR
Androgen receptor

2

20

Small-scale

0.584

High

765026

CTNB1
Catenin beta-1

2

6

Small-scale

0.584

High

697428

DCK
Deoxycytidine kinase

2

0

High-throughput

0.576

High

347315

BAG2
BAG family molecular chaperone regulator 2

2

2

High-throughput

0.549

High

854288

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

1122338

SCRIB
Protein scribble homolog

1

4

High-throughput

0.536

High

1281073

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

0

High-throughput

0.518

High

1407459

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.501

High

1328669

KCD17
BTB/POZ domain-containing protein KCTD17

1

10

High-throughput

0.489

High

129414

MEN1
Menin

1

2

High-throughput

0.479

High

143246

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

260439

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

474279

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

537887

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

607098

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

776127

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776247

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

851811

NKX21
Homeobox protein Nkx-2.1

1

20

High-throughput

0.479

High

986711

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1045756

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1088007

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1095102

KLF10
Krueppel-like factor 10

1

5

High-throughput

0.479

High

1114267

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1127155

RBM39
RNA-binding protein 39

1

6

Small-scale

0.479

High

1133653

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1255486

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1367241

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1430939

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

11

Small-scale

0.479

High

1430940

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

532954

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

1335888

RN169
E3 ubiquitin-protein ligase RNF169

1

2

Small-scale

0.445

High

106632

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

412586

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

1416716

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

142412

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.407

High

1104090

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1430941

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.407

High


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Last updated: 11Aug2025