Protein: I2BP2
Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)

Gene: I2BP2, IRF2BP2
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q7Z5L9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002327 - immature B cell differentiation
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571617

IRF2
Interferon regulatory factor 2

5

5

Small-scale

0.728

High

1121011

VGLL4
Transcription cofactor vestigial-like protein 4

5

2

Small-scale

0.719

High

1279284

I2BP1
Interferon regulatory factor 2-binding protein 1

5

9

Small-scale

0.712

High

584113

FOSL2
Fos-related antigen 2

4

9

High-throughput

0.691

High

1279297

CCNL2
Cyclin-L2

3

2

High-throughput

0.667

High

1279288

SIR6
NAD-dependent protein deacylase sirtuin-6

3

5

High-throughput

0.650

High

404167

GCR
Glucocorticoid receptor

3

20

Small-scale

0.640

High

1279305

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

3

13

Small-scale

0.640

High

1279295

UPP
Uracil phosphoribosyltransferase homolog

3

0

High-throughput

0.638

High

1106347

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

5

Small-scale

0.631

High

681851

RBTN2
Rhombotin-2

2

9

High-throughput

0.628

High

716487

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

930962

HSP72
Heat shock-related 70 kDa protein 2

2

3

High-throughput

0.601

High

143082

NFIB
Nuclear factor 1 B-type

2

19

High-throughput

0.584

High

260128

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

372429

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

520167

ANDR
Androgen receptor

2

20

Small-scale

0.584

High

833983

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.584

High

1087832

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1133495

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

410920

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

16

High-throughput

0.576

High

1145745

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

17

High-throughput

0.576

High

1279294

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

High-throughput

0.571

High

347137

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.549

High

1122274

SCRIB
Protein scribble homolog

1

5

High-throughput

0.536

High

1279285

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

886996

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.527

High

641621

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

16

High-throughput

0.526

High

1279287

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1279301

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

880938

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.494

High

1279304

ACH10
Neuronal acetylcholine receptor subunit alpha-10

1

2

High-throughput

0.489

High

181530

TBXT
T-box transcription factor T

1

2

High-throughput

0.479

High

188316

HDAC3
Histone deacetylase 3

1

7

Small-scale

0.479

High

216182

MTG8R
Protein CBFA2T2

1

1

Small-scale

0.479

High

242138

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

270256

MTG16
Protein CBFA2T3

1

1

Small-scale

0.479

High

278375

NCOR1
Nuclear receptor corepressor 1

1

13

Small-scale

0.479

High

323461

TRI37
E3 ubiquitin-protein ligase TRIM37

1

9

High-throughput

0.479

High

378502

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

396415

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

414109

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

474093

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487474

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

587126

ITF2
Transcription factor 4

1

2

Small-scale

0.479

High

587496

TFE2
Transcription factor E2-alpha

1

2

Small-scale

0.479

High

589037

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

605208

TAL1
T-cell acute lymphocytic leukemia protein 1

1

2

Small-scale

0.479

High

636106

CD11B
Cyclin-dependent kinase 11B

1

2

Small-scale

0.479

High

685248

PAX6
Paired box protein Pax-6

1

10

High-throughput

0.479

High

695824

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

703162

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

714230

PML
Protein PML

1

5

High-throughput

0.479

High

725276

TLX1
T-cell leukemia homeobox protein 1

1

16

High-throughput

0.479

High

768536

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

776210

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

801392

HSPA9
Stress-70 protein, mitochondrial

1

7

High-throughput

0.479

High

837061

ELK3
ETS domain-containing protein Elk-3

1

5

High-throughput

0.479

High

851780

NKX21
Homeobox protein Nkx-2.1

1

17

High-throughput

0.479

High

872476

SOX2
Transcription factor SOX-2

1

18

Small-scale

0.479

High

944692

KLF3
Krueppel-like factor 3

1

7

High-throughput

0.479

High

967821

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.479

High

995667

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

1048020

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.479

High

1091120

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.479

High

1095090

KLF10
Krueppel-like factor 10

1

4

High-throughput

0.479

High

1113537

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1126974

RBM39
RNA-binding protein 39

1

6

Small-scale

0.479

High

1156755

E2F4
Transcription factor E2F4

1

4

High-throughput

0.479

High

1250602

BCOR
BCL-6 corepressor

1

6

Small-scale

0.479

High

1279280

I2BP2
Interferon regulatory factor 2-binding protein 2

1

15

Small-scale

0.479

High

1279282

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1279286

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.479

High

1279289

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1279290

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1279291

SP7
Transcription factor Sp7

1

7

High-throughput

0.479

High

1279292

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1279293

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.479

High

1279298

SIN3A
Paired amphipathic helix protein Sin3a

1

4

Small-scale

0.479

High

1279299

MINT
Msx2-interacting protein

1

9

Small-scale

0.479

High

1279300

HTF4
Transcription factor 12

1

2

Small-scale

0.479

High

1279302

SSBP3
Single-stranded DNA-binding protein 3

1

5

Small-scale

0.479

High

1279303

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

1279306

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

7

Small-scale

0.479

High

1279307

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1279309

HM20A
High mobility group protein 20A

1

14

Small-scale

0.479

High

1279313

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1279314

TES
Testin

1

4

High-throughput

0.479

High

1279315

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1279316

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

1279317

TRRAP
Transformation/transcription domain-associated protein

1

4

Small-scale

0.479

High

1279318

NCOR2
Nuclear receptor corepressor 2

1

8

Small-scale

0.479

High

1279281

LDB1
LIM domain-binding protein 1

1

0

Small-scale

0.458

High

1279296

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

1279312

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

330222

VENTX
Homeobox protein VENTX

1

10

High-throughput

0.445

High

537419

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.445

High

1279310

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

412176

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.437

High

369187

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1094364

CSN1
COP9 signalosome complex subunit 1

1

0

High-throughput

0.426

High

1279283

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1226969

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.407

High

418233

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1279311

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

0

Small-scale

0.249

Low

1259238

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

1279308

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025