HitPredict

Interactor 1: KAPB (P06245)
cAMP-dependent protein kinase type 2 (PKA 2) (EC 2.7.11.11)
Gene: TPK2

Interactor 2: YAK1 (P14680)
Dual specificity protein kinase YAK1 (EC 2.7.12.1)
Gene: YAK1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	16319894, 20489023
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0010737 - protein kinase A signaling GO:0016310 - phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Sc			1 807
+	Sc
		412635 KAPA_YEAST (5-380): 1.15e-151: 435: 66.49		YAK1_YEAST (20-807): 0: 549: 100.00
+	Hs
		682218 AKT2_HUMAN (4-369): 3.58e-152: 439: 33.87		AKT3_HUMAN (259-697): 1.64e-124: 384: 17.14
+	Hs
		681681 AKT2_HUMAN (4-369): 3.58e-152: 439: 33.87		AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11
+	Hs
		408561 AKT1_HUMAN (4-375): 3.08e-149: 432: 34.75		KPCB_HUMAN (170-678): 9.9e-123: 385: 16.89
+	Hs
		682081 AKT3_HUMAN (4-376): 7.56e-151: 436: 34.31		AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11
+	Hs
		566289 KPCL_HUMAN (32-380): 2.64e-145: 429: 37.15		KPCA_HUMAN (174-679): 6.25e-122: 383: 16.41
+	Mm
		682096 AKT1_MOUSE (4-375): 2.1e-149: 432: 35.01		AKT1_MOUSE (266-670): 3.71e-123: 380: 15.88
+	Hs
		681680 AKT1_HUMAN (4-375): 3.08e-149: 432: 34.75		AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11
+	Hs
		568561 AKT1_HUMAN (4-375): 3.08e-149: 432: 34.75		KAPCA_HUMAN (332-670): 8.2e-121: 369: 19.03
+	Hs
		682166 AKT2_HUMAN (4-369): 3.58e-152: 439: 33.87		CDK3_HUMAN (366-640): 1.91e-118: 361: 24.44
+	Hs
		568657 KAPCA_HUMAN (35-380): 9.1e-149: 426: 47.69		DYR1A_HUMAN (247-807): 2.62e-116: 371: 27.67
+	Hs
		623866 KPCL_HUMAN (32-380): 2.64e-145: 429: 37.15		CDK2_HUMAN (366-630): 4.81e-121: 368: 28.24
+	Hs
		568531 KAPCA_HUMAN (35-380): 9.1e-149: 426: 47.69		KAPCA_HUMAN (332-670): 8.2e-121: 369: 19.03
+	Hs
		568542 KAPCB_HUMAN (32-380): 2.2e-148: 425: 48.14		KAPCA_HUMAN (332-670): 8.2e-121: 369: 19.03
+	Hs
		568843 KAPCA_HUMAN (35-380): 9.1e-149: 426: 47.69		DYR1B_HUMAN (261-802): 2.04e-116: 368: 27.87
+	Hs
		414773 AKT1_HUMAN (4-375): 3.08e-149: 432: 34.75		CDK1_HUMAN (366-707): 3.58e-117: 358: 23.43