Protein: CPNS1
Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)

Gene: CPNS1, CAPNS1
Organism: Homo sapiens
Interactions: 84
UniProt ID: P04632

Gene Ontology (top 5):
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

412917

CAN1
Calpain-1 catalytic subunit

7

14

Small-scale

0.747

High

412927

CAN2
Calpain-2 catalytic subunit

4

14

Small-scale

0.686

High

412973

CPNS2
Calpain small subunit 2

3

17

High-throughput

0.667

High

412923

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.643

High

377906

TNFA
Tumor necrosis factor

3

0

High-throughput

0.638

High

412939

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

412928

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.571

High

412933

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.571

High

412952

GRB2
Growth factor receptor-bound protein 2

2

1

High-throughput

0.571

High

412975

KCTD7
BTB/POZ domain-containing protein KCTD7

1

7

Small-scale

0.561

High

412962

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.549

High

136655

TRAF5
TNF receptor-associated factor 5

1

2

High-throughput

0.541

High

412921

CDK4
Cyclin-dependent kinase 4

1

8

High-throughput

0.541

High

412946

PAR2
Proteinase-activated receptor 2

1

3

High-throughput

0.541

High

412950

RAB1A
Ras-related protein Rab-1A

1

2

High-throughput

0.541

High

412932

MAP4
Microtubule-associated protein 4

1

10

High-throughput

0.536

High

412951

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.518

High

412965

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.518

High

412987

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.518

High

412930

RASA1
Ras GTPase-activating protein 1

1

13

Small-scale

0.515

High

412948

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.501

High

412937

ARRC
Arrestin-C

1

1

High-throughput

0.494

High

412944

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.494

High

412976

CF418
Cilia- and flagella-associated protein 418

1

0

High-throughput

0.493

High

412960

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

1

High-throughput

0.489

High

412935

IL2RG
Cytokine receptor common subunit gamma

1

3

Small-scale

0.481

High

412938

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.481

High

131655

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

240466

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

317124

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

370392

KNG1
Kininogen-1

1

1

High-throughput

0.479

High

388880

FINC
Fibronectin

1

5

High-throughput

0.479

High

395305

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

400093

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

412920

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

412924

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

412926

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.479

High

412931

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

412941

FNTB
Protein farnesyltransferase subunit beta

1

3

High-throughput

0.479

High

412942

CDK7
Cyclin-dependent kinase 7

1

8

High-throughput

0.479

High

412943

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

412945

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

412949

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

412956

CDC20
Cell division cycle protein 20 homolog

1

3

High-throughput

0.479

High

412957

CUL3
Cullin-3

1

8

Small-scale

0.479

High

412958

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

412959

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

412966

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

412969

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

412970

NEDD1
Protein NEDD1

1

1

High-throughput

0.479

High

412972

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.479

High

412974

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

412977

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.479

High

412979

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

Small-scale

0.479

High

412981

ATG5
Autophagy protein 5

1

3

High-throughput

0.479

High

412982

ANLN
Anillin

1

4

High-throughput

0.479

High

412985

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

412986

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

412984

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

High-throughput

0.460

High

412918

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

412922

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

412934

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

412967

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

412955

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

412919

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

412929

FILA
Filaggrin

1

2

Small-scale

0.445

High

227304

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.437

High

352830

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

412925

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

412936

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

412940

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

412963

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

412971

DUS19
Dual specificity protein phosphatase 19

1

5

High-throughput

0.437

High

412983

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

412989

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

412988

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

412978

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

1

7

High-throughput

0.417

High

412954

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

Small-scale

0.388

High

412947

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.282

High

412968

SMYD1
Histone-lysine N-methyltransferase SMYD1

1

0

High-throughput

0.279

Low

412953

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

412961

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

412964

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

412980

SIL1
Nucleotide exchange factor SIL1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025