HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	2013279
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 215
+	Hs
		449545 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00
+	Hs
		625125 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		414748 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		643326 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		414816 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91
+	Hs
		567641 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00
+	Hs
		415030 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CIC_HUMAN (3-96): 2.76e-12: 67: 22.34
+	Hs
		414863 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39