HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.947

The method score is based on:

Property Details
Experiments 26496610, 28514442, 21654808, 33961781, 7903056, 8479754
Identification Methods affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004672 - protein kinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 297
Hs

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Last updated: 15 Jul 2024