Protein: P73
Tumor protein p73 (p53-like transcription factor) (p53-related protein)

Gene: P73, TP73
Organism: Homo sapiens
Interactions: 167
UniProt ID: O15350

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186805

P63
Tumor protein 63

7

14

Small-scale

0.960

High

186679

P53
Cellular tumor antigen p53

7

14

Small-scale

0.959

High

186668

P73
Tumor protein p73

5

14

Small-scale

0.933

High

186677

ABL1
Tyrosine-protein kinase ABL1

5

5

Small-scale

0.924

High

186733

MDM2
E3 ubiquitin-protein ligase Mdm2

13

10

Small-scale

0.763

High

186718

YAP1
Transcriptional coactivator YAP1

11

20

Small-scale

0.757

High

186738

EP300
Histone acetyltransferase p300

8

20

Small-scale

0.754

High

186685

HCK
Tyrosine-protein kinase HCK

1

5

Small-scale

0.747

High

186788

ITCH
E3 ubiquitin-protein ligase Itchy homolog

6

15

Small-scale

0.742

High

179651

MDM4
Protein Mdm4

6

10

Small-scale

0.732

High

186790

ASPP1
Apoptosis-stimulating of p53 protein 1

1

16

Small-scale

0.681

High

186810

WWOX
WW domain-containing oxidoreductase

3

5

Small-scale

0.678

High

186717

NEDD4
E3 ubiquitin-protein ligase NEDD4

3

15

Small-scale

0.660

High

186814

DAXX
Death domain-associated protein 6

2

4

Small-scale

0.649

High

186752

ASPP2
Apoptosis-stimulating of p53 protein 2

1

16

Small-scale

0.647

High

186775

IASPP
RelA-associated inhibitor

1

15

Small-scale

0.647

High

186797

IER2
Immediate early response gene 2 protein

3

0

High-throughput

0.638

High

131584

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

15

Small-scale

0.634

High

186736

KPCD
Protein kinase C delta type

2

4

Small-scale

0.634

High

186792

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

3

Small-scale

0.634

High

186750

TDG
G/T mismatch-specific thymine DNA glycosylase

2

2

Small-scale

0.633

High

186781

KAT2B
Histone acetyltransferase KAT2B

2

15

Small-scale

0.631

High

186747

SKP2
S-phase kinase-associated protein 2

2

3

High-throughput

0.628

High

186825

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

2

High-throughput

0.628

High

177738

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

10

Small-scale

0.624

High

186678

MYC
Myc proto-oncogene protein

2

5

Small-scale

0.624

High

186749

HDAC1
Histone deacetylase 1

2

7

Small-scale

0.624

High

186742

TP53B
TP53-binding protein 1

1

7

High-throughput

0.618

High

186669

SOCS1
Suppressor of cytokine signaling 1

2

3

Small-scale

0.611

High

186725

MLF1
Myeloid leukemia factor 1

2

2

High-throughput

0.611

High

186791

ANM6
Protein arginine N-methyltransferase 6

2

6

High-throughput

0.611

High

169822

AURKA
Aurora kinase A

1

5

Small-scale

0.610

High

186780

CBP
CREB-binding protein

2

16

Small-scale

0.602

High

186786

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

6

Small-scale

0.596

High

186723

PMS2
Mismatch repair endonuclease PMS2

2

2

Small-scale

0.594

High

186735

CEBPZ
CCAAT/enhancer-binding protein zeta

1

1

Small-scale

0.589

High

186806

DSN1
Kinetochore-associated protein DSN1 homolog

2

0

High-throughput

0.585

High

186704

NFYB
Nuclear transcription factor Y subunit beta

2

1

Small-scale

0.584

High

167768

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

9

Small-scale

0.578

High

186674

PIAS1
E3 SUMO-protein ligase PIAS1

1

10

Small-scale

0.578

High

186682

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.578

High

186696

CCNA2
Cyclin-A2

1

3

Small-scale

0.578

High

186722

PLK1
Serine/threonine-protein kinase PLK1

1

7

Small-scale

0.578

High

186821

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.578

High

186698

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

2

Small-scale

0.573

High

186729

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.573

High

186672

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

5

Small-scale

0.561

High

186688

FBSP1
F-box/SPRY domain-containing protein 1

1

6

Small-scale

0.561

High

186695

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

8

Small-scale

0.561

High

186715

RL5
Large ribosomal subunit protein uL18

1

1

Small-scale

0.561

High

186727

RL11
Large ribosomal subunit protein uL5

1

2

Small-scale

0.561

High

186731

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.561

High

186746

TIF1B
Transcription intermediary factor 1-beta

1

15

Small-scale

0.561

High

186748

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.561

High

186756

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.561

High

186784

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

6

Small-scale

0.561

High

186795

RANB9
Ran-binding protein 9

1

5

Small-scale

0.561

High

186820

PLAL1
Zinc finger protein PLAGL1

1

7

Small-scale

0.561

High

186754

NFYC
Nuclear transcription factor Y subunit gamma

2

0

Small-scale

0.559

High

186720

AMPH
Amphiphysin

1

4

Small-scale

0.552

High

186796

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.549

High

186702

CCNE1
G1/S-specific cyclin-E1

1

4

Small-scale

0.536

High

186719

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.536

High

186739

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.536

High

186745

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

Small-scale

0.536

High

186774

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.536

High

186802

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

15

High-throughput

0.536

High

186816

HSPB8
Heat shock protein beta-8

1

5

High-throughput

0.536

High

186687

HMGB1
High mobility group protein B1

1

9

Small-scale

0.527

High

186697

FLNA
Filamin-A

1

5

Small-scale

0.527

High

186710

HSPA9
Stress-70 protein, mitochondrial

1

10

Small-scale

0.523

High

186671

CCNT1
Cyclin-T1

1

9

Small-scale

0.515

High

186759

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

186764

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

186755

UBE3C
Ubiquitin-protein ligase E3C

1

18

Small-scale

0.512

High

186812

HECW2
E3 ubiquitin-protein ligase HECW2

1

15

Small-scale

0.512

High

186684

SP1
Transcription factor Sp1

1

7

Small-scale

0.501

High

186691

CCNB1
G2/mitotic-specific cyclin-B1

1

3

Small-scale

0.501

High

186700

CCND1
G1/S-specific cyclin-D1

1

6

Small-scale

0.501

High

186703

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

186734

SP3
Transcription factor Sp3

1

10

Small-scale

0.501

High

186773

PRLD2
PRELI domain-containing protein 2

1

1

High-throughput

0.489

High

186728

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.481

High

186730

UBC9
SUMO-conjugating enzyme UBC9

1

8

Small-scale

0.481

High

186741

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

6

Small-scale

0.481

High

186804

HIPK2
Homeodomain-interacting protein kinase 2

1

14

Small-scale

0.481

High

186807

HIPK3
Homeodomain-interacting protein kinase 3

1

18

Small-scale

0.481

High

142722

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

174460

TRI66
Tripartite motif-containing protein 66

1

18

High-throughput

0.479

High

186670

KDM1A
Lysine-specific histone demethylase 1A

1

2

Small-scale

0.479

High

186673

DNJB6
DnaJ homolog subfamily B member 6

1

6

High-throughput

0.479

High

186675

UBE4B
Ubiquitin conjugation factor E4 B

1

7

Small-scale

0.479

High

186676

DRC4
Dynein regulatory complex subunit 4

1

2

High-throughput

0.479

High

186680

JUN
Transcription factor Jun

1

4

Small-scale

0.479

High

186681

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.479

High

186683

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.479

High

186686

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

186689

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

186690

ADHX
Alcohol dehydrogenase class-3

1

3

High-throughput

0.479

High

186692

ETS2
Protein C-ets-2

1

5

Small-scale

0.479

High

186694

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.479

High

186699

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.479

High

186701

MYL9
Myosin regulatory light polypeptide 9

1

5

High-throughput

0.479

High

186705

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

186706

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

186707

FUS
RNA-binding protein FUS

1

10

High-throughput

0.479

High

186709

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.479

High

186711

CDN1A
Cyclin-dependent kinase inhibitor 1

1

4

Small-scale

0.479

High

186712

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.479

High

186713

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

186714

MAGA2
Melanoma-associated antigen 2

1

8

Small-scale

0.479

High

186721

CCNG1
Cyclin-G1

1

8

Small-scale

0.479

High

186726

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

186737

ACK1
Activated CDC42 kinase 1

1

12

Small-scale

0.479

High

186740

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

186744

TRI32
E3 ubiquitin-protein ligase TRIM32

1

10

Small-scale

0.479

High

186751

CUL1
Cullin-1

1

5

Small-scale

0.479

High

186753

RUNX2
Runt-related transcription factor 2

1

2

Small-scale

0.479

High

186757

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

Small-scale

0.479

High

186761

CBPC2
Cytosolic carboxypeptidase 2

1

4

High-throughput

0.479

High

186762

DAB2P
Disabled homolog 2-interacting protein

1

4

High-throughput

0.479

High

186763

TTLL5
Tubulin polyglutamylase TTLL5

1

4

High-throughput

0.479

High

186765

SAS6
Spindle assembly abnormal protein 6 homolog

1

5

High-throughput

0.479

High

186766

TPC11
Trafficking protein particle complex subunit 11

1

3

High-throughput

0.479

High

186767

R144B
E3 ubiquitin-protein ligase RNF144B

1

5

Small-scale

0.479

High

186769

N4BP2
NEDD4-binding protein 2

1

1

High-throughput

0.479

High

186770

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.479

High

186771

CF206
Cilia- and flagella-associated protein 206

1

1

High-throughput

0.479

High

186772

ASPM
Abnormal spindle-like microcephaly-associated protein

1

10

High-throughput

0.479

High

186776

STAG1
Cohesin subunit SA-1

1

1

High-throughput

0.479

High

186777

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

Small-scale

0.479

High

186778

AKAP1
A-kinase anchor protein 1, mitochondrial

1

4

High-throughput

0.479

High

186779

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

186782

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

6

High-throughput

0.479

High

186783

KAT5
Histone acetyltransferase KAT5

1

4

Small-scale

0.479

High

186785

SPSB1
SPRY domain-containing SOCS box protein 1

1

8

High-throughput

0.479

High

186789

PIWL1
Piwi-like protein 1

1

9

High-throughput

0.479

High

186793

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

186794

MED15
Mediator of RNA polymerase II transcription subunit 15

1

16

Small-scale

0.479

High

186798

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

186799

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

3

High-throughput

0.479

High

186800

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

186801

RNF38
E3 ubiquitin-protein ligase RNF38

1

6

High-throughput

0.479

High

186803

CDT1
DNA replication factor Cdt1

1

2

High-throughput

0.479

High

186808

JPH1
Junctophilin-1

1

2

High-throughput

0.479

High

186811

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.479

High

186815

DAPK2
Death-associated protein kinase 2

1

4

Small-scale

0.479

High

186818

AGO2
Protein argonaute-2

1

9

High-throughput

0.479

High

186819

AGO1
Protein argonaute-1

1

10

High-throughput

0.479

High

186822

DYN3
Dynamin-3

1

2

High-throughput

0.479

High

186823

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

186824

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.479

High

186708

TALDO
Transaldolase

1

0

High-throughput

0.458

High

186716

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

186724

OAZ1
Ornithine decarboxylase antizyme 1

1

0

Small-scale

0.458

High

186817

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.458

High

186693

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

1

Small-scale

0.445

High

186732

BAT1
b(0,+)-type amino acid transporter 1

1

2

High-throughput

0.445

High

186743

NPRL3
GATOR1 complex protein NPRL3

1

3

High-throughput

0.437

High

186758

MTHSD
Methenyltetrahydrofolate synthase domain-containing protein

1

3

High-throughput

0.437

High

186768

TRM11
tRNA

1

3

High-throughput

0.437

High

186809

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

172274

XPO1
Exportin-1

1

2

Small-scale

0.408

High

186760

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

186787

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

186813

RBL2A
Rab-like protein 2A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025