HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 457
+	Hs
		960090 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		625378 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		960281 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		960271 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		684635 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		414775 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684636 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62