Protein: HECW1
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)

Gene: HECW1
Organism: Homo sapiens
Interactions: 35
UniProt ID: Q76N89

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475963

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

849351

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

895825

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

919762

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.647

High

932538

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1176337

HECW1
E3 ubiquitin-protein ligase HECW1

1

15

Small-scale

0.647

High

1176340

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

Small-scale

0.647

High

808720

YAP1
Transcriptional coactivator YAP1

1

17

Small-scale

0.618

High

1176349

HECW2
E3 ubiquitin-protein ligase HECW2

1

16

High-throughput

0.618

High

1176350

HERC5
E3 ISG15--protein ligase HERC5

1

15

Small-scale

0.618

High

170549

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

12

High-throughput

0.609

High

946405

EREP3
Protein ENTREP3

2

14

High-throughput

0.574

High

386980

P53
Cellular tumor antigen p53

1

16

Small-scale

0.561

High

1131047

VAX1
Ventral anterior homeobox 1

2

3

High-throughput

0.553

High

150723

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.552

High

1148113

RNF43
E3 ubiquitin-protein ligase RNF43

1

7

Small-scale

0.552

High

1176342

TSC1
Hamartin

1

11

High-throughput

0.541

High

1176346

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.541

High

1176339

ILDR1
Immunoglobulin-like domain-containing receptor 1

1

5

High-throughput

0.536

High

1176345

MPP8
M-phase phosphoprotein 8

1

10

High-throughput

0.536

High

1176348

FXL15
F-box/LRR-repeat protein 15

1

11

Small-scale

0.515

High

132322

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

20

High-throughput

0.508

High

1176343

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

14

High-throughput

0.508

High

739596

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

20

Small-scale

0.501

High

992589

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.501

High

1176347

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

14

Small-scale

0.489

High

152188

TMG1
Transmembrane gamma-carboxyglutamic acid protein 1

1

14

High-throughput

0.489

High

1176341

TM171
Transmembrane protein 171

1

4

High-throughput

0.489

High

1176344

ZN707
Zinc finger protein 707

1

1

High-throughput

0.489

High

336530

SODC
Superoxide dismutase [Cu-Zn]

1

5

Small-scale

0.479

High

1138054

GFI1B
Zinc finger protein Gfi-1b

1

2

High-throughput

0.464

High

1176338

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

845975

SCNNB
Amiloride-sensitive sodium channel subunit beta

1

20

Small-scale

0.457

High

847292

SSRD
Translocon-associated protein subunit delta

1

2

Small-scale

0.437

High


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Last updated: 15 Jul 2024