HitPredict

Interactor 1: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Interactor 2: HSP79 (P32590)
Heat shock protein homolog SSE2
Gene: SSE2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 562 Sc			1 693
+	Sc
		416209 SIR2_YEAST (1-562): 0: 847: 100.00		HSP7F_YEAST (1-693): 0: 1007: 75.61
+	Sc
		695211 HST2_YEAST (256-526): 8.82e-86: 272: 31.03		HSP7F_YEAST (1-693): 0: 1007: 75.61
+	Hs
		504364 SIR2_HUMAN (217-561): 3.35e-119: 359: 28.57		HSP7C_HUMAN (2-645): 0: 851: 26.92
+	Hs
		714048 SIR1_HUMAN (202-525): 7.26e-102: 325: 37.76		HS71L_HUMAN (2-655): 0: 853: 26.21
+	Hs
		714080 SIR3_HUMAN (241-545): 2.18e-101: 313: 32.59		HS71L_HUMAN (2-655): 0: 853: 26.21
+	Hs
		871799 SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30		HSP72_HUMAN (2-644): 0: 845: 27.27
+	Hs
		714019 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		HS71L_HUMAN (2-655): 0: 853: 26.21
+	Hs
		504402 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		HSP7C_HUMAN (2-645): 0: 851: 26.92
+	Hs
		871671 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		HSP72_HUMAN (2-644): 0: 845: 27.27
+	Sc
		416182 SIR2_YEAST (1-562): 0: 847: 100.00		HSP72_YEAST (1-429): 1.15e-71: 246: 34.95
+	Sc
		416181 SIR2_YEAST (1-562): 0: 847: 100.00		HSP71_YEAST (1-429): 5.26e-71: 244: 34.72
+	Sc
		491991 HST1_YEAST (113-560): 0: 582: 66.81		HSP71_YEAST (1-429): 5.26e-71: 244: 34.72
+	Hs
		714355 SIR1_HUMAN (202-525): 7.26e-102: 325: 37.76		HSP74_HUMAN (6-650): 2.75e-140: 432: 38.18
+	Hs
		714434 SIR3_HUMAN (241-545): 2.18e-101: 313: 32.59		HSP74_HUMAN (6-650): 2.75e-140: 432: 38.18
+	Hs
		714433 SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30		HSP74_HUMAN (6-650): 2.75e-140: 432: 38.18
+	Hs
		714307 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		HSP74_HUMAN (6-650): 2.75e-140: 432: 38.18
+	Hs
		320882 SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95		HS74L_HUMAN (6-687): 1.48e-139: 431: 34.60
+	At
		1106791 SIR4_ARATH (206-529): 5.43e-79: 255: 17.89		BIP2_ARATH (1-638): 2.59e-72: 249: 29.57
+	At
		1277489 SIR4_ARATH (206-529): 5.43e-79: 255: 17.89		BIP1_ARATH (1-638): 8.13e-71: 244: 29.10
+	Sc
		491992 HST3_YEAST (240-520): 6.42e-70: 233: 27.19		HSP71_YEAST (1-429): 5.26e-71: 244: 34.72