HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	16169070, 34079125
Identification Methods	two hybrid, proximity labelling technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0098978 - glutamatergic synapse
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 1919
+	Mm
		1143428 Q8CEH8_MOUSE (1-140): 3.54e-76: 224: 95.00		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		430366 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		430150 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81