HitPredict

Interactor 1: CD3E (P07766)
T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
Gene: CD3E

Interactor 2: ES8L1 (Q8TE68)
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)
Gene: EPS8L1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	17617578, 18644376
Identification Methods	affinity chromatography technology, unspecified method, filamentous phage display, peptide array, anti tag coimmunoprecipitation, pull down, nuclear magnetic resonance, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042608 - T cell receptor binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 207 Hs			1 723
+	Hs
		430697 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		EPS8_HUMAN (3-716): 0: 754: 34.96
+	Hs
		430722 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		ES8L2_HUMAN (6-709): 0: 722: 39.37
+	Hs
		430712 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		ES8L3_HUMAN (11-614): 7.35e-173: 509: 29.71
+	Hs
		411550 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		LCK_HUMAN (417-701): 3.51e-67: 232: 15.36
+	Hs
		208975 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		NCK2_HUMAN (478-605): 1.59e-36: 143: 23.70
+	Hs
		430679 CD3E_HUMAN (1-207): 5.3e-142: 395: 100.00		NCK1_HUMAN (478-605): 5.2e-32: 130: 22.96