Protein: TPA
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]

Gene: TPA, PLAT
Organism: Homo sapiens
Interactions: 58
UniProt ID: P00750

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366514

PAI2
Plasminogen activator inhibitor 2

2

20

High-throughput

0.811

High

366517

IC1
Plasma protease C1 inhibitor

2

20

High-throughput

0.811

High

366536

SPB6
Serpin B6

2

20

High-throughput

0.811

High

366557

ZPI
Protein Z-dependent protease inhibitor

2

20

High-throughput

0.811

High

366510

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

5

Small-scale

0.778

High

366515

PAI1
Plasminogen activator inhibitor 1

2

20

Small-scale

0.778

High

366540

NOTC2
Neurogenic locus notch homolog protein 2

2

11

High-throughput

0.776

High

366542

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

9

Small-scale

0.696

High

366551

NEUS
Neuroserpin

1

20

Small-scale

0.692

High

366520

HEPS
Serine protease hepsin

1

13

High-throughput

0.691

High

366525

A2AP
Alpha-2-antiplasmin

1

20

High-throughput

0.691

High

366538

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.691

High

366552

TMPSD
Transmembrane protease serine 13

1

16

High-throughput

0.691

High

366558

ST14
Suppressor of tumorigenicity 14 protein

1

17

High-throughput

0.691

High

366543

FGL1
Fibrinogen-like protein 1

3

5

High-throughput

0.667

High

366521

GDN
Glia-derived nexin

1

20

High-throughput

0.665

High

366272

FA10
Coagulation factor X

1

16

Small-scale

0.647

High

366450

UROK
Urokinase-type plasminogen activator

1

17

Small-scale

0.647

High

366507

TPA
Tissue-type plasminogen activator

1

15

Small-scale

0.647

High

366511

FINC
Fibronectin

1

10

Small-scale

0.647

High

366513

A4
Amyloid-beta precursor protein

1

20

Small-scale

0.647

High

366516

IPSP
Plasma serine protease inhibitor

1

20

Small-scale

0.647

High

366518

TETN
Tetranectin

1

3

Small-scale

0.647

High

366546

LAMA3
Laminin subunit alpha-3

1

16

Small-scale

0.647

High

366553

PDGFC
Platelet-derived growth factor C

1

15

Small-scale

0.647

High

366550

TMM25
Transmembrane protein 25

3

0

High-throughput

0.638

High

366526

IBP1
Insulin-like growth factor-binding protein 1

2

6

High-throughput

0.628

High

366523

PGS2
Decorin

1

5

High-throughput

0.618

High

366544

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

8

High-throughput

0.618

High

192052

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

366539

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

366556

FBX2
F-box only protein 2

2

3

High-throughput

0.601

High

366509

IFN14
Interferon alpha-14

2

0

High-throughput

0.585

High

366073

THRB
Prothrombin

1

15

Small-scale

0.575

High

366524

MSMB
Beta-microseminoprotein

1

1

High-throughput

0.536

High

366530

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.536

High

366531

CL3L1
C-C motif chemokine 3-like 1

1

1

High-throughput

0.536

High

366535

CALX
Calnexin

1

10

High-throughput

0.536

High

366549

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.513

High

366519

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.501

High

366522

ANXA2
Annexin A2

1

1

Small-scale

0.501

High

366532

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

9

Small-scale

0.501

High

366533

LAMA1
Laminin subunit alpha-1

1

9

Small-scale

0.501

High

366534

CALR
Calreticulin

1

10

Small-scale

0.501

High

366537

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

366529

TIMP2
Metalloproteinase inhibitor 2

1

4

High-throughput

0.479

High

366547

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

366554

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

366527

HMGB1
High mobility group protein B1

1

5

Small-scale

0.445

High

366528

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

2

High-throughput

0.445

High

366508

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.437

High

366512

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.437

High

366548

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

366555

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.437

High

366541

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

170603

CLGN
Calmegin

1

10

High-throughput

0.407

High

366545

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025