HitPredict

Interactor 1: SYEP (P07814)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Gene: EPRS1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16055720
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1512 Hs			1 1319
+	Hs
		430996 SYEP_HUMAN (1-1512): 0: 1810: 100.00		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		125096 SYEP_HUMAN (1-1512): 0: 1810: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Sc
		804900 SYEC_YEAST (5-707): 0: 721: 42.04		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Hs
		814482 SYQ_HUMAN (159-704): 0: 631: 31.19		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		643764 SYTC_HUMAN (703-1410): 0: 573: 15.62		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Sc
		389009 SYTC_YEAST (704-1407): 5.25e-165: 517: 14.95		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Sc
		765306 SYEC_YEAST (5-707): 0: 721: 42.04		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41
+	Hs
		125239 SYQ_HUMAN (159-704): 0: 631: 31.19		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Sc
		765318 SYEM_YEAST (197-509): 8.1e-102: 338: 22.25		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41