HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: BMR1A (P36894)
Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
Gene: BMPR1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27684187, 22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0042803 - protein homodimerization activity GO:0043025 - neuronal cell body
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 532
+	Hs
		437951 HS90B_HUMAN (19-732): 0: 1059: 86.13		BMR1A_HUMAN (1-532): 5.05e-164: 477: 100.00
+	Hs
		431603 HS90A_HUMAN (1-732): 0: 1087: 100.00		TGFR1_HUMAN (26-532): 9.84e-139: 412: 49.22
+	Hs
		432072 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACV1C_HUMAN (57-531): 1.11e-133: 398: 50.63
+	Hs
		431602 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACV1B_HUMAN (47-532): 1.83e-128: 385: 49.19
+	Hs
		431606 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACVL1_HUMAN (57-531): 4.4e-128: 385: 45.72
+	Hs
		438363 HS90B_HUMAN (19-732): 0: 1059: 86.13		ACV1C_HUMAN (57-531): 1.11e-133: 398: 50.63
+	Hs
		437952 HS90B_HUMAN (19-732): 0: 1059: 86.13		ACV1B_HUMAN (47-532): 1.83e-128: 385: 49.19
+	Hs
		431607 HS90A_HUMAN (1-732): 0: 1087: 100.00		TGFR2_HUMAN (38-524): 3.81e-115: 353: 27.43
+	Hs
		431836 HS90A_HUMAN (1-732): 0: 1087: 100.00		AVR2B_HUMAN (81-529): 7.14e-111: 341: 30.02
+	Hs
		438157 HS90B_HUMAN (19-732): 0: 1059: 86.13		AVR2B_HUMAN (81-529): 7.14e-111: 341: 30.02
+	Ce
		595733 HSP90_CAEEL (14-732): 0: 960: 74.83		DAF1_CAEEL (74-523): 1.31e-96: 308: 30.39
+	Hs
		431905 HS90A_HUMAN (1-732): 0: 1087: 100.00		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23
+	Hs
		438218 HS90B_HUMAN (19-732): 0: 1059: 86.13		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23
+	Ce
		839899 HSP90_CAEEL (14-732): 0: 960: 74.83		DAF4_CAEEL (59-514): 7.47e-36: 144: 27.00
+	Hs
		1086118 H90B4_HUMAN (30-604): 0: 571: 62.61		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23