HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: TYRO3 (Q06418)
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
Gene: TYRO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001764 - neuron migration GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 890
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (125-821): 0: 552: 19.39
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (72-826): 3.64e-180: 547: 19.92
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (119-820): 7.18e-173: 528: 20.61
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (116-832): 1.86e-165: 509: 21.01
+	Hs
		431591 HS90A_HUMAN (1-732): 0: 1087: 100.00		TIE1_HUMAN (43-796): 2.59e-153: 481: 24.13
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (203-829): 5.58e-141: 445: 26.19
+	Hs
		431444 HS90A_HUMAN (1-732): 0: 1087: 100.00		MET_HUMAN (495-790): 3.89e-65: 240: 41.67
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		431764 HS90A_HUMAN (1-732): 0: 1087: 100.00		RON_HUMAN (500-793): 2.58e-59: 223: 41.95
+	Hs
		431435 HS90A_HUMAN (1-732): 0: 1087: 100.00		RET_HUMAN (514-790): 1.89e-55: 210: 39.93
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (513-780): 3.2e-53: 204: 39.56
+	Hs
		431765 HS90A_HUMAN (1-732): 0: 1087: 100.00		FAK1_HUMAN (510-832): 6.04e-53: 202: 35.14
+	Hs
		69196 HS90B_HUMAN (19-732): 0: 1059: 86.13		A9UEZ6_HUMAN (519-878): 3.4e-53: 204: 36.76
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (42-257): 7.52e-27: 119: 16.59
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (6-230): 2.63e-19: 95.6: 18.22
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (42-257): 7.52e-27: 119: 16.59
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (7-315): 1.59e-17: 89.8: 14.60
+	Hs
		431568 HS90A_HUMAN (1-732): 0: 1087: 100.00		UFO_HUMAN (6-344): 1.91e-14: 79.8: 14.56
+	Hs
		431788 HS90A_HUMAN (1-732): 0: 1087: 100.00		MERTK_HUMAN (6-315): 1.52e-12: 73.6: 15.71