HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: DNJC7 (Q99615)
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Gene: DNAJC7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.913

Property	Details
Experiments	18620420, 35053380, 20661446, 19875381, 12853476
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 494
+	Hs
		438464 HS90B_HUMAN (19-732): 0: 1059: 86.13		DNJC7_HUMAN (1-494): 2.58e-85: 273: 100.00
+	Hs
		174556 HS90A_HUMAN (1-732): 0: 1087: 100.00		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Hs
		111934 K9JA46_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		431574 HS90A_HUMAN (1-732): 0: 1087: 100.00		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		174561 HS90B_HUMAN (19-732): 0: 1059: 86.13		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Hs
		431774 HS90A_HUMAN (1-732): 0: 1087: 100.00		SPAG1_HUMAN (31-263): 1.7e-21: 100: 19.23
+	Mm
		432427 HS90A_MOUSE (1-732): 0: 1083: 97.82		PPP5_MOUSE (139-260): 3.58e-16: 82.8: 13.93
+	Hs
		437930 HS90B_HUMAN (19-732): 0: 1059: 86.13		STIP1_HUMAN (4-156): 5.02e-23: 104: 25.49
+	Hs
		432268 HS90A_HUMAN (1-732): 0: 1087: 100.00		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Hs
		111935 K9JA46_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79
+	Hs
		431681 HS90A_HUMAN (1-732): 0: 1087: 100.00		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79
+	Mm
		513680 HS90B_MOUSE (19-732): 0: 1063: 86.98		PPP5_MOUSE (139-260): 3.58e-16: 82.8: 13.93
+	Dm
		365481 HSP83_DROME (15-732): 0: 1034: 78.41		Q9VPN5_DROME (7-171): 3.79e-22: 101: 29.09
+	Hs
		438533 HS90B_HUMAN (19-732): 0: 1059: 86.13		RPAP3_HUMAN (2-223): 2.82e-09: 61.6: 11.92
+	Hs
		438021 HS90B_HUMAN (19-732): 0: 1059: 86.13		PPP5_HUMAN (242-391): 7.28e-09: 60.1: 31.79
+	Ce
		183711 HSP90_CAEEL (14-732): 0: 960: 74.83		STIP1_CAEEL (24-195): 7.35e-34: 131: 25.70
+	At
		878278 HS902_ARATH (15-732): 0: 982: 68.24		HSOP2_ARATH (2-362): 5.24e-14: 76.2: 14.25
+	Hs
		174598 ENPL_HUMAN (14-701): 0: 898: 46.78		OGT1_HUMAN (3-401): 1.62e-31: 130: 13.59
+	Ca
		804535 HSP90_CANAL (12-732): 0: 914: 60.50		Q5ADP3_CANAL (7-147): 6.83e-21: 98.6: 14.09
+	Mm
		435924 ENPL_MOUSE (14-732): 0: 901: 45.07		PPP5_MOUSE (139-260): 3.58e-16: 82.8: 13.93