HitPredict

Interactor 1: HS90A (P07901)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)
Gene: Hsp90aa1

Interactor 2: SIM1 (Q61045)
Single-minded homolog 1 (mSIM1)
Gene: SIM1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9020169
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 733 Mm			1 765
+	Hs
		431737 HS90A_HUMAN (1-733): 0: 1078: 98.23		SIM1_HUMAN (1-765): 0: 827: 96.61
+	Hs
		431844 HS90A_HUMAN (1-733): 0: 1078: 98.23		SIM2_HUMAN (1-660): 2.92e-165: 494: 54.91
+	Hs
		438165 HS90B_HUMAN (19-733): 0: 1049: 85.87		SIM2_HUMAN (1-660): 2.92e-165: 494: 54.91
+	Hs
		431903 HS90A_HUMAN (1-733): 0: 1078: 98.23		HIF1A_HUMAN (2-713): 2.25e-140: 435: 26.82
+	Mm
		432431 HS90A_MOUSE (1-733): 0: 1083: 100.00		HIF1A_MOUSE (2-559): 1.49e-138: 430: 30.55
+	Hs
		431556 HS90A_HUMAN (1-733): 0: 1078: 98.23		ARNT_HUMAN (2-663): 5.61e-137: 425: 17.01
+	Hs
		432201 HS90A_HUMAN (1-733): 0: 1078: 98.23		EPAS1_HUMAN (2-632): 8.54e-131: 411: 21.91
+	Hs
		438217 HS90B_HUMAN (19-733): 0: 1049: 85.87		HIF1A_HUMAN (2-713): 2.25e-140: 435: 26.82
+	Hs
		432385 HS90A_HUMAN (1-733): 0: 1078: 98.23		HIF3A_HUMAN (2-642): 5.49e-124: 387: 26.32
+	Hs
		126097 HS90A_HUMAN (1-733): 0: 1078: 98.23		BMAL1_HUMAN (2-483): 1.33e-122: 382: 23.13
+	Hs
		431594 HS90A_HUMAN (1-733): 0: 1078: 98.23		AHR_HUMAN (5-694): 5.81e-108: 350: 17.85
+	Hs
		438468 HS90B_HUMAN (19-733): 0: 1049: 85.87		NPAS1_HUMAN (2-491): 2.56e-120: 375: 30.91
+	Rn
		783943 HS90A_RAT (1-733): 0: 1085: 99.86		AHR_RAT (5-645): 1.72e-102: 336: 19.14
+	Mm
		432410 HS90A_MOUSE (1-733): 0: 1083: 100.00		AHR_MOUSE (5-710): 7.8e-101: 331: 18.96
+	Hs
		432199 HS90A_HUMAN (1-733): 0: 1078: 98.23		NPAS2_HUMAN (2-695): 3.81e-97: 321: 16.80
+	Mm
		513659 HS90B_MOUSE (19-733): 0: 1053: 86.15		AHR_MOUSE (5-710): 7.8e-101: 331: 18.96
+	Dm
		1096504 Q9VAY2_DROME (15-701): 2.45e-180: 536: 46.35		SIMA_DROME (2-607): 1.95e-97: 332: 24.54