HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: ACV1B (P36896)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: ACVR1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 505
+	Hs
		738438 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		ACV1B_HUMAN (1-505): 2.52e-154: 451: 100.00
+	Hs
		738322 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		436181 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		738321 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		738323 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		BMR1A_HUMAN (19-505): 4.06e-145: 428: 49.29
+	Hs
		738517 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		738521 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		436183 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		738527 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		738516 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Hs
		738519 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		TGFR1_HUMAN (33-505): 3.15e-139: 412: 70.17
+	Mm
		983316 RAC2_MOUSE (1-193): 1.09e-76: 229: 54.12		ACVL1_MOUSE (23-502): 9.78e-135: 400: 47.42
+	Hs
		739935 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		TGFR2_HUMAN (69-499): 4.18e-121: 368: 31.05
+	Hs
		900458 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		925266 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		436293 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		950982 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		893991 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		545365 RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68
+	Hs
		915666 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		BMPR2_HUMAN (1-497): 1.81e-95: 313: 28.68