HitPredict

Interactor 1: TNR16 (P08138)
Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
Gene: NGFR

Interactor 2: SORT (Q99523)
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Gene: SORT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	20159974, 21261755, 14985763
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016020 - membrane GO:0048406 - nerve growth factor binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 831
+	Rn
		222451 TNR16_RAT (3-427): 3.25e-110: 332: 92.24		SORT_RAT (1-831): 0: 1053: 90.73
+	Mm
		1161530 TNR16_MOUSE (3-427): 1.09e-106: 323: 91.80		SORT_MOUSE (1-831): 0: 1048: 90.61
+	Rn
		222453 NRADD_RAT (227-427): 2.44e-54: 182: 38.73		SORT_RAT (1-831): 0: 1053: 90.73
+	Mm
		1161528 NRADD_MOUSE (227-427): 3.22e-55: 184: 35.78		SORT_MOUSE (1-831): 0: 1048: 90.61
+	Hs
		645819 CD27_HUMAN (11-140): 9.34e-27: 109: 24.63		SORT_HUMAN (1-831): 0: 1064: 100.00
+	Hs
		436636 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		SORC2_HUMAN (25-742): 0: 768: 24.17
+	Hs
		436648 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		SORC3_HUMAN (25-755): 0: 757: 23.48
+	Mm
		1322285 TNR16_MOUSE (3-427): 1.09e-106: 323: 91.80		SORC2_MOUSE (23-750): 0: 777: 24.27