HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CDK18 (Q07002)
Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3)
Gene: CDK18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	26186194, 28514442, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 474
+	Hs
		431772 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK18_HUMAN (1-474): 1.57e-165: 477: 100.00
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (141-436): 1.07e-146: 422: 52.69
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (141-443): 4.63e-144: 416: 49.84
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (141-436): 1.07e-146: 422: 52.69
+	Hs
		300621 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK14_HUMAN (3-465): 8.83e-137: 403: 44.85
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (141-443): 4.63e-144: 416: 49.84
+	Hs
		438004 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK7_HUMAN (138-470): 1.68e-134: 393: 35.59
+	Hs
		300620 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK14_HUMAN (3-465): 8.83e-137: 403: 44.85
+	Hs
		438445 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK15_HUMAN (107-452): 1.54e-131: 389: 51.29
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (141-431): 4.4e-133: 387: 55.29
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (141-430): 6.84e-137: 397: 51.54
+	Hs
		431662 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK7_HUMAN (138-470): 1.68e-134: 393: 35.59
+	Hs
		432173 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK15_HUMAN (107-452): 1.54e-131: 389: 51.29
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (141-431): 4.4e-133: 387: 55.29
+	Ca
		793050 HSP90_CANAL (8-724): 0: 929: 60.42		CDK1_CANAL (141-425): 2.98e-134: 391: 52.76
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (141-429): 4.35e-134: 390: 48.66
+	Sc
		365744 HSP82_YEAST (12-724): 0: 927: 61.26		PHO85_YEAST (143-427): 1.26e-129: 379: 52.54
+	Sc
		339312 HSP82_YEAST (12-724): 0: 927: 61.26		CDK1_YEAST (139-427): 1.47e-128: 376: 50.00
+	Sc
		543138 HSC82_YEAST (13-724): 0: 922: 60.22		PHO85_YEAST (143-427): 1.26e-129: 379: 52.54
+	Sc
		339406 HSC82_YEAST (13-724): 0: 922: 60.22		CDK1_YEAST (139-427): 1.47e-128: 376: 50.00