Protein: XPO5
Exportin-5 (Exp5) (Ran-binding protein 21)

Gene: XPO5
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q9HAV4

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005049 - nuclear export signal receptor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

981703

RAN
GTP-binding nuclear protein Ran

2

20

Small-scale

0.831

High

539905

RALB
Ras-related protein Ral-B

2

7

High-throughput

0.726

High

374940

RASH
GTPase HRas

1

5

High-throughput

0.691

High

976572

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.691

High

1307525

RBM45
RNA-binding protein 45

1

7

High-throughput

0.691

High

1089877

ILF3
Interleukin enhancer-binding factor 3

3

6

Small-scale

0.672

High

373188

MYC
Myc proto-oncogene protein

3

12

High-throughput

0.656

High

1208759

CL12A
C-type lectin domain family 12 member A

4

3

High-throughput

0.630

High

580837

PVR
Poliovirus receptor

2

1

High-throughput

0.628

High

1120124

RB33A
Ras-related protein Rab-33A

1

1

High-throughput

0.618

High

126810

RHOD
Rho-related GTP-binding protein RhoD

1

19

High-throughput

0.618

High

775603

NU214
Nuclear pore complex protein Nup214

1

17

Small-scale

0.618

High

971104

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.618

High

988723

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.618

High

1437766

RHOF
Rho-related GTP-binding protein RhoF

1

18

High-throughput

0.618

High

1394323

VSIG2
V-set and immunoglobulin domain-containing protein 2

3

10

High-throughput

0.609

High

1067729

EP300
Histone acetyltransferase p300

2

13

High-throughput

0.584

High

1228653

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

10

High-throughput

0.574

High

1291362

LCA5
Lebercilin

2

6

High-throughput

0.571

High

318883

RHBT1
Rho-related BTB domain-containing protein 1

1

15

High-throughput

0.553

High

1396631

RHOV
Rho-related GTP-binding protein RhoV

1

15

High-throughput

0.553

High

50700

HACL2
2-hydroxyacyl-CoA lyase 2

2

5

High-throughput

0.549

High

683340

TNR5
Tumor necrosis factor receptor superfamily member 5

2

14

High-throughput

0.549

High

771237

APJ
Apelin receptor

2

17

High-throughput

0.549

High

835394

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

8

High-throughput

0.549

High

1325924

MFD4A
Major facilitator superfamily domain-containing protein 4A

2

6

High-throughput

0.549

High

349575

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

535554

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.536

High

638526

FPR1
fMet-Leu-Phe receptor

1

20

High-throughput

0.536

High

690388

STOM
Stomatin

1

6

High-throughput

0.536

High

857563

NOTC1
Neurogenic locus notch homolog protein 1

1

8

High-throughput

0.536

High

872760

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

1086703

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.536

High

1098758

NDK3
Nucleoside diphosphate kinase 3

1

1

High-throughput

0.536

High

1363231

AQP3
Aquaporin-3

1

2

High-throughput

0.536

High

1404415

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1437788

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

3

High-throughput

0.536

High

619929

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.521

High

277408

TP4A3
Protein tyrosine phosphatase type IVA 3

1

16

High-throughput

0.515

High

831456

CCNF
Cyclin-F

1

9

High-throughput

0.515

High

848443

MAGA6
Melanoma-associated antigen 6

1

4

High-throughput

0.515

High

1437767

NEK6
Serine/threonine-protein kinase Nek6

1

18

High-throughput

0.515

High

1437789

GSTK1
Glutathione S-transferase kappa 1

1

1

High-throughput

0.515

High

1437793

PHLA3
Pleckstrin homology-like domain family A member 3

1

1

High-throughput

0.515

High

1369703

KLK6
Kallikrein-6

1

5

High-throughput

0.515

High

1106711

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.508

High

964461

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

996342

EF1A1
Elongation factor 1-alpha 1

1

8

Small-scale

0.501

High

390769

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

71251

HIDE1
Protein HIDE1

1

1

High-throughput

0.489

High

182780

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

376644

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.489

High

465653

IGF1R
Insulin-like growth factor 1 receptor

1

14

High-throughput

0.489

High

669212

EDNRA
Endothelin-1 receptor

1

15

High-throughput

0.489

High

709281

AA2BR
Adenosine receptor A2b

1

10

High-throughput

0.489

High

733078

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

8

High-throughput

0.489

High

749280

CD70
CD70 antigen

1

4

High-throughput

0.489

High

914347

EFNA4
Ephrin-A4

1

7

High-throughput

0.489

High

936127

PAR2
Proteinase-activated receptor 2

1

20

High-throughput

0.489

High

1057700

TNR9
Tumor necrosis factor receptor superfamily member 9

1

14

High-throughput

0.489

High

1101666

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.489

High

1132581

FXYD3
FXYD domain-containing ion transport regulator 3

1

4

High-throughput

0.489

High

1142183

P2RY6
P2Y purinoceptor 6

1

20

High-throughput

0.489

High

1207303

KRBX4
KRAB domain-containing protein 4

1

8

High-throughput

0.489

High

1249510

VSTM1
V-set and transmembrane domain-containing protein 1

1

5

High-throughput

0.489

High

1291687

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

6

High-throughput

0.489

High

1292551

AMGO1
Amphoterin-induced protein 1

1

1

High-throughput

0.489

High

1325160

TM130
Transmembrane protein 130

1

1

High-throughput

0.489

High

1395522

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

3

High-throughput

0.489

High

1399617

OPALI
Opalin

1

5

High-throughput

0.489

High

1430961

UN93B
Protein unc-93 homolog B1

1

9

High-throughput

0.489

High

1437772

GP173
Probable G-protein coupled receptor 173

1

8

High-throughput

0.489

High

1437777

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

1437779

HCST
Hematopoietic cell signal transducer

1

4

High-throughput

0.489

High

1437782

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

2

High-throughput

0.489

High

1437784

ITBP2
Integrin beta-1-binding protein 2

1

2

High-throughput

0.489

High

1437794

GPR45
Probable G-protein coupled receptor 45

1

15

High-throughput

0.489

High

1437795

NPTN
Neuroplastin

1

11

High-throughput

0.489

High

1437786

ZN346
Zinc finger protein 346

1

0

Small-scale

0.480

High

157871

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

176089

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.479

High

189001

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.479

High

191103

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

223343

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

242975

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

260475

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

350138

SNAI1
Zinc finger protein SNAI1

1

15

High-throughput

0.479

High

1428366

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

352557

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

363880

EGFR
Epidermal growth factor receptor

1

13

High-throughput

0.479

High

459338

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

508657

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

520381

ANDR
Androgen receptor

1

13

High-throughput

0.479

High

582624

PPAP
Prostatic acid phosphatase

1

4

High-throughput

0.479

High

589733

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

605816

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

11

Small-scale

0.479

High

610050

VGFR1
Vascular endothelial growth factor receptor 1

1

10

High-throughput

0.479

High

664817

CCND1
G1/S-specific cyclin-D1

1

8

High-throughput

0.479

High

696553

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

731626

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

769220

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

777770

VGFR3
Vascular endothelial growth factor receptor 3

1

10

High-throughput

0.479

High

791735

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

879479

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

890401

NU153
Nuclear pore complex protein Nup153

1

20

Small-scale

0.479

High

913810

ZN131
Zinc finger protein 131

1

12

High-throughput

0.479

High

937921

FOXA1
Hepatocyte nuclear factor 3-alpha

1

9

High-throughput

0.479

High

975255

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

985000

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.479

High

1005111

RNF4
E3 ubiquitin-protein ligase RNF4

1

8

High-throughput

0.479

High

1007656

CCNA1
Cyclin-A1

1

4

High-throughput

0.479

High

1096929

FADD
FAS-associated death domain protein

1

4

Small-scale

0.479

High

1101194

CLN3
Battenin

1

3

Small-scale

0.479

High

1107225

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1114340

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1122558

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

9

High-throughput

0.479

High

1135817

HAPR1
HUWE1-associated protein modifying stress responses 1

1

3

High-throughput

0.479

High

1152475

T22D1
TSC22 domain family protein 1

1

9

High-throughput

0.479

High

1161407

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

High-throughput

0.479

High

1164085

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

20

High-throughput

0.479

High

1229688

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

1255604

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1271868

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1276812

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1280511

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

1288586

ZN598
E3 ubiquitin-protein ligase ZNF598

1

10

High-throughput

0.479

High

1295565

MIB1
E3 ubiquitin-protein ligase MIB1

1

11

High-throughput

0.479

High

1312428

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.479

High

1334942

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1364600

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1367316

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1370853

FUBP2
Far upstream element-binding protein 2

1

7

Small-scale

0.479

High

1393710

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1403347

RUFY1
RUN and FYVE domain-containing protein 1

1

11

High-throughput

0.479

High

1403578

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

High-throughput

0.479

High

1433933

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1437769

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1437773

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1437776

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

1437778

ANFY1
Rabankyrin-5

1

8

High-throughput

0.479

High

1437781

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1437783

MRT4
mRNA turnover protein 4 homolog

1

3

Small-scale

0.479

High

1437785

NUP50
Nuclear pore complex protein Nup50

1

17

High-throughput

0.479

High

1437790

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1437791

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1437792

YTHD2
YTH domain-containing family protein 2

1

10

High-throughput

0.479

High

1437796

NEMO
NF-kappa-B essential modulator

1

7

High-throughput

0.479

High

680747

CATS
Cathepsin S

1

2

High-throughput

0.470

High

1286911

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.470

High

1281616

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1437770

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

710760

EPHA8
Ephrin type-A receptor 8

1

5

High-throughput

0.457

High

166420

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

7

High-throughput

0.445

High

171584

S27A2
Long-chain fatty acid transport protein 2

1

16

High-throughput

0.445

High

190260

MOT4
Monocarboxylate transporter 4

1

8

High-throughput

0.445

High

344328

PTBP3
Polypyrimidine tract-binding protein 3

1

10

High-throughput

0.445

High

388302

GLPA
Glycophorin-A

1

3

High-throughput

0.445

High

564389

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.445

High

1437768

S17A5
Sialin

1

5

High-throughput

0.445

High

1437775

S39A9
Zinc transporter ZIP9

1

7

High-throughput

0.445

High

389519

FINC
Fibronectin

1

3

High-throughput

0.437

High

412634

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

460875

CATB
Cathepsin B

1

3

High-throughput

0.437

High

565476

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

614735

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

14

High-throughput

0.437

High

630363

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

14

High-throughput

0.437

High

643077

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

693093

DPP4
Dipeptidyl peptidase 4

1

4

High-throughput

0.437

High

787080

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

10

High-throughput

0.437

High

1163424

CAH9
Carbonic anhydrase 9

1

6

Small-scale

0.437

High

1203088

TM41B
Transmembrane protein 41B

1

2

High-throughput

0.437

High

1249224

LMBRL
Protein LMBR1L

1

6

High-throughput

0.437

High

1250200

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1310877

LMTK2
Serine/threonine-protein kinase LMTK2

1

18

High-throughput

0.437

High

1330400

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.437

High

1360938

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1418455

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

1437771

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.437

High

1437780

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

14

High-throughput

0.437

High

1437787

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

887234

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

1129

SIM26
Small integral membrane protein 26

1

5

High-throughput

0.407

High

262313

SCN2B
Sodium channel regulatory subunit beta-2

1

17

High-throughput

0.407

High

292280

S22A3
Solute carrier family 22 member 3

1

10

High-throughput

0.407

High

425202

IPSP
Plasma serine protease inhibitor

1

1

Small-scale

0.407

High

652251

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

8

High-throughput

0.407

High

1090034

NTCP2
Ileal sodium/bile acid cotransporter

1

1

High-throughput

0.407

High

1175900

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

9

High-throughput

0.407

High

1237828

AR26L
Putative ankyrin repeat domain-containing protein 26-like protein

1

12

High-throughput

0.407

High

1280817

S35E3
Solute carrier family 35 member E3

1

7

High-throughput

0.407

High

1292376

UN93A
Protein unc-93 homolog A

1

9

High-throughput

0.407

High

1293910

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

11

High-throughput

0.407

High

1309405

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

8

High-throughput

0.407

High

1333873

MFSD9
Major facilitator superfamily domain-containing protein 9

1

9

High-throughput

0.407

High

1335729

MOT11
Monocarboxylate transporter 11

1

8

High-throughput

0.407

High

1381029

S35B4
Nucleotide sugar transporter SLC35B4

1

10

High-throughput

0.407

High

1412071

S39A3
Zinc transporter ZIP3

1

7

High-throughput

0.407

High

1437774

S22AB
Solute carrier family 22 member 11

1

7

High-throughput

0.407

High

165825

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

0

High-throughput

0.313

High

329592

STBD1
Starch-binding domain-containing protein 1

2

0

High-throughput

0.313

High

935385

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.279

Low

1022477

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1092393

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

1159235

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1431622

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.279

Low

1109437

SERC3
Serine incorporator 3

1

0

High-throughput

0.269

Low

1326910

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025