HitPredict

Interactor 1: RASN (P08556)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: Nras

Interactor 2: RGL2 (Q61193)
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
Gene: RGL2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Mm			1 778
+	Mm
		699619 RASK_MOUSE (1-189): 1.94e-85: 251: 86.77		RGL2_MOUSE (11-778): 0: 870: 100.00
+	Hs
		171532 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGL2_HUMAN (11-778): 0: 831: 89.45
+	Hs
		349692 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGL1_HUMAN (49-761): 0: 610: 30.54
+	Mm
		1113379 RASH_MOUSE (1-188): 1.22e-89: 262: 86.70		RGL3_MOUSE (42-738): 0: 561: 34.36
+	Hs
		349360 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGL3_HUMAN (42-737): 0: 542: 34.05
+	Ce
		103461 LET60_CAEEL (1-181): 1.74e-88: 259: 76.80		G4SFM6_CAEEL (59-771): 1.72e-172: 520: 23.97
+	Ce
		612368 LET60_CAEEL (1-181): 1.74e-88: 259: 76.80		Q19852_CAEEL (59-771): 3.75e-169: 512: 23.32
+	Dm
		442998 RAS1_DROME (1-165): 2.18e-90: 264: 85.46		Q86BI2_DROME (45-740): 3.76e-166: 501: 26.69
+	Dm
		443004 RAS1_DROME (1-165): 2.18e-90: 264: 85.46		Q9GR11_DROME (45-740): 4.28e-166: 500: 26.69
+	Dm
		443005 RAS1_DROME (1-165): 2.18e-90: 264: 85.46		Q9U4U5_DROME (45-740): 2.53e-161: 494: 26.69
+	Hs
		349267 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		SOS1_HUMAN (39-695): 8.49e-148: 468: 20.37
+	Hs
		349312 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGRF1_HUMAN (19-516): 3.08e-108: 360: 20.66
+	Hs
		349455 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		GRP3_HUMAN (93-769): 7.01e-107: 344: 18.20
+	Hs
		349311 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RPGF1_HUMAN (13-526): 1.52e-99: 333: 22.33
+	Hs
		349443 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGPS2_HUMAN (200-620): 1.45e-92: 303: 21.61
+	Hs
		349466 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		RGDSR_HUMAN (227-514): 1.59e-90: 294: 33.79
+	Mm
		976137 RASH_MOUSE (1-188): 1.22e-89: 262: 86.70		GNDS_MOUSE (52-241): 9.31e-27: 118: 20.89
+	Hs
		349279 RASH_HUMAN (1-188): 1.22e-89: 262: 86.70		GNDS_HUMAN (10-220): 7.16e-26: 116: 20.33
+	Ce
		105960 LET60_CAEEL (1-181): 1.74e-88: 259: 76.80		RPGF_CAEEL (213-413): 1.57e-11: 70.5: 27.86
+	Ce
		612367 LET60_CAEEL (1-181): 1.74e-88: 259: 76.80		Q19770_CAEEL (163-482): 1.34e-10: 67: 21.30