HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.917

The method score is based on:

Property Details
Experiments 23794705, 26285778, 16537482, 20624990, 20802513
Identification Methods enzymatic study, cross-linking study, amplified luminescent proximity homogeneous assay, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PSI~Sema, PSI~TIG, Sema~Sema, Sema~TIG, TIG~TIG
Common GO terms GO:0001886 - endothelial cell morphogenesis
GO:0001889 - liver development
GO:0002116 - semaphorin receptor complex
GO:0004713 - protein tyrosine kinase activity
GO:0005008 - hepatocyte growth factor receptor activity
and 32 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024