HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	21918175, 25326665
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009925 - basal plasma membrane GO:0016310 - phosphorylation and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 1342
+	Hs
		383546 MET_HUMAN (1-1390): 0: 1283: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337803 MET_HUMAN (1-1390): 0: 1283: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383759 RON_HUMAN (23-1390): 0: 934: 32.70		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Mm
		555013 MET_MOUSE (1-1381): 0: 1246: 89.57		NTRK3_MOUSE (467-978): 1.09e-125: 411: 21.05
+	Hs
		435499 MET_HUMAN (1-1390): 0: 1283: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		441441 MET_HUMAN (1-1390): 0: 1283: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Mm
		554968 MET_MOUSE (1-1381): 0: 1246: 89.57		EPHB2_MOUSE (627-1004): 2.65e-117: 392: 26.40
+	Hs
		383631 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383710 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Mm
		554979 MET_MOUSE (1-1381): 0: 1246: 89.57		EPHA4_MOUSE (656-996): 1.58e-103: 354: 27.79
+	Hs
		441462 MET_HUMAN (1-1390): 0: 1283: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		441461 MET_HUMAN (1-1390): 0: 1283: 100.00		TXK_HUMAN (707-969): 2.69e-44: 171: 37.12
+	Hs
		411279 MET_HUMAN (1-1390): 0: 1283: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	At
		85349 ERL1_ARATH (522-1388): 0: 580: 13.17		BAME1_ARATH (334-1000): 3.89e-132: 434: 17.91
+	At
		221809 CLV1_ARATH (565-1339): 0: 566: 14.48		BAME1_ARATH (334-1000): 3.89e-132: 434: 17.91
+	Hs
		337359 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	At
		83729 CLV1_ARATH (565-1339): 0: 566: 14.48		Y5182_ARATH (355-1007): 3.22e-132: 430: 14.35
+	Hs
		665374 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		665142 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		665385 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79