HitPredict

Interactor 1: A4 (P08592)
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
Gene: App

Interactor 2: APBB1 (P46933)
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Gene: APBB1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.870

The method score is based on:

Property Details
Experiments 23531501, 9045663, 8955346, 9461550
Identification Methods affinity chromatography technology, coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains APP_amyloid~PID
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0030182 - neuron differentiation
GO:0030198 - extracellular matrix organization
GO:0030426 - growth cone
and 10 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 770
Rn

1 711
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024