Protein: GCN1
eIF-2-alpha kinase activator GCN1 (General control non-derepressible protein 1) (Translational activator GCN1)

Gene: GCN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 225
UniProt ID: P33892

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006417 - regulation of translation
GO:0006448 - regulation of translational elongation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

755119

GCN20
Protein GCN20

8

9

Small-scale

0.756

High

584356

GCN2
eIF-2-alpha kinase GCN2

5

8

Small-scale

0.720

High

755082

IMB2
Importin subunit beta-2

3

10

High-throughput

0.662

High

755161

GIR2
Protein GIR2

3

0

Small-scale

0.649

High

755190

RS10A
Small ribosomal subunit protein eS10A

2

5

Small-scale

0.631

High

755135

RBG2
Ribosome-interacting GTPase 2

4

10

Small-scale

0.626

High

523513

HSP71
Heat shock protein SSA1

3

14

High-throughput

0.624

High

526312

HSP72
Heat shock protein SSA2

3

14

High-throughput

0.624

High

678500

YIH1
Protein IMPACT homolog

2

1

Small-scale

0.614

High

434976

RS3
Small ribosomal subunit protein uS3

2

5

High-throughput

0.611

High

734408

BTAF1
TATA-binding protein-associated factor MOT1

2

4

High-throughput

0.588

High

738088

MYO4
Myosin-4

2

7

High-throughput

0.588

High

755092

GGA2
ADP-ribosylation factor-binding protein GGA2

2

1

High-throughput

0.588

High

755125

SMC3
Structural maintenance of chromosomes protein 3

2

3

High-throughput

0.588

High

751685

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

3

3

High-throughput

0.587

High

755120

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

10

High-throughput

0.584

High

392503

HSP82
ATP-dependent molecular chaperone HSP82

2

13

High-throughput

0.571

High

544348

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.571

High

755168

SXM1
Importin beta SMX1

2

7

High-throughput

0.571

High

755177

IMB1
Importin subunit beta-1

2

10

High-throughput

0.571

High

449328

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

2

0

High-throughput

0.563

High

721814

XPO1
Exportin-1

2

7

High-throughput

0.558

High

755105

IMB4
Importin subunit beta-4

2

11

High-throughput

0.558

High

755199

RUVB2
RuvB-like protein 2

2

8

High-throughput

0.558

High

394417

EF1A
Elongation factor 1-alpha

2

7

Small-scale

0.552

High

726203

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

3

High-throughput

0.549

High

755121

LSB3
LAS seventeen-binding protein 3

1

2

High-throughput

0.541

High

623820

MYO2
Myosin-2

2

6

High-throughput

0.537

High

755080

MAK5
ATP-dependent RNA helicase MAK5

2

16

High-throughput

0.537

High

755126

MTR4
ATP-dependent RNA helicase DOB1

2

11

High-throughput

0.537

High

755145

NAT10
RNA cytidine acetyltransferase

2

2

High-throughput

0.537

High

417069

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.536

High

531295

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

613555

ADT2
ADP,ATP carrier protein 2

1

4

High-throughput

0.536

High

655426

RS3A2
Small ribosomal subunit protein eS1B

1

5

High-throughput

0.536

High

661603

MPCP
Mitochondrial phosphate carrier protein

1

6

High-throughput

0.536

High

701508

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

4

High-throughput

0.536

High

738054

MKK2
MAP kinase kinase MKK2/SSP33

1

19

High-throughput

0.536

High

755074

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

755087

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.536

High

755101

FHP
Flavohemoprotein

1

2

High-throughput

0.536

High

755113

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

4

High-throughput

0.536

High

755123

NMD5
Nonsense-mediated mRNA decay protein 5

1

8

High-throughput

0.536

High

755138

BRE5
UBP3-associated protein BRE5

1

10

High-throughput

0.536

High

755180

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.536

High

755198

AHA1
Hsp90 co-chaperone AHA1

1

3

High-throughput

0.536

High

755204

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.536

High

455490

PMM
Phosphomannomutase

1

0

High-throughput

0.513

High

755108

TPM2
Tropomyosin-2

1

4

High-throughput

0.494

High

755133

SDS23
Protein SDS23

1

4

High-throughput

0.494

High

755192

TGL5
Triacylglycerol lipase 5

1

1

High-throughput

0.494

High

382003

H4
Histone H4

1

4

High-throughput

0.489

High

386658

TBB
Tubulin beta chain

1

4

High-throughput

0.489

High

486118

TBA1
Tubulin alpha-1 chain

1

9

High-throughput

0.489

High

486442

TBA3
Tubulin alpha-3 chain

1

9

High-throughput

0.489

High

575423

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.489

High

656954

BUR1
Serine/threonine-protein kinase BUR1

1

9

High-throughput

0.489

High

750581

UBC6
Ubiquitin-conjugating enzyme E2 6

1

6

High-throughput

0.489

High

755083

OLA1
Obg-like ATPase 1

1

8

High-throughput

0.489

High

755111

MOB1
DBF2 kinase activator protein MOB1

1

6

High-throughput

0.489

High

755116

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

755117

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

1

High-throughput

0.489

High

755185

RBX1
RING-box protein HRT1

1

4

High-throughput

0.489

High

383615

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.479

High

410039

RL25
Large ribosomal subunit protein uL23

1

5

High-throughput

0.479

High

430824

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

9

Small-scale

0.479

High

433554

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

435879

RS13
Small ribosomal subunit protein uS15

1

5

High-throughput

0.479

High

441821

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

458554

SEC4
Ras-related protein SEC4

1

5

Small-scale

0.479

High

502954

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.479

High

504138

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.479

High

512922

RS8A
Small ribosomal subunit protein eS8A

1

5

High-throughput

0.479

High

579138

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.479

High

597423

EF3A
Elongation factor 3A

1

11

High-throughput

0.479

High

645355

XRN1
5'-3' exoribonuclease 1

1

2

Small-scale

0.479

High

647075

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.479

High

647741

RFA1
Replication factor A protein 1

1

7

Small-scale

0.479

High

670544

SIS1
Protein SIS1

1

7

High-throughput

0.479

High

674527

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.479

High

679541

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

747272

RSSA1
Small ribosomal subunit protein uS2A

1

8

High-throughput

0.479

High

747784

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

753280

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

755072

RS27A
Small ribosomal subunit protein eS27A

1

5

High-throughput

0.479

High

755081

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

755086

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.479

High

755093

RPN10
26S proteasome regulatory subunit RPN10

1

4

High-throughput

0.479

High

755100

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.479

High

755109

MLP2
Protein MLP2

1

11

High-throughput

0.479

High

755118

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.479

High

755129

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

755142

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.479

High

755151

NUM1
Nuclear migration protein NUM1

1

8

High-throughput

0.479

High

755153

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

755156

ESP1
Separin

1

3

High-throughput

0.479

High

755169

DHR1
Probable ATP-dependent RNA helicase DHR1

1

9

High-throughput

0.479

High

755187

MCA1
Metacaspase-1

1

1

High-throughput

0.479

High

755191

TMA46
Translation machinery-associated protein 46

1

4

High-throughput

0.479

High

755194

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

755172

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.470

High

755181

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.460

High

755084

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

755163

DOP1
Protein DOP1

1

0

High-throughput

0.458

High

456381

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.445

High

481574

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.445

High

555303

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.445

High

638998

VPS1
Vacuolar protein sorting-associated protein 1

1

2

High-throughput

0.445

High

646121

NPR1
Nitrogen permease reactivator protein

1

16

High-throughput

0.445

High

675872

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

734767

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.445

High

736842

APE2
Aminopeptidase 2, mitochondrial

1

6

High-throughput

0.445

High

740487

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.445

High

741286

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

746571

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.445

High

752081

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

755069

MDJ1
DnaJ homolog 1, mitochondrial

1

10

High-throughput

0.445

High

755076

MCR1
NADH-cytochrome b5 reductase 2

1

2

High-throughput

0.445

High

755091

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

755097

XDJ1
DnaJ protein homolog XDJ1

1

9

High-throughput

0.445

High

755104

PIC2
Mitochondrial phosphate carrier protein 2

1

4

High-throughput

0.445

High

755106

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

755122

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.445

High

755131

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.445

High

755132

PHB2
Prohibitin-2

1

8

High-throughput

0.445

High

755141

JJJ1
J protein JJJ1

1

9

High-throughput

0.445

High

755143

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.445

High

755146

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.445

High

755165

HMO1
High mobility group protein 1

1

7

High-throughput

0.445

High

755166

SNX41
Sorting nexin-41

1

3

High-throughput

0.445

High

755171

PUF6
Pumilio homology domain family member 6

1

3

High-throughput

0.445

High

755195

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.445

High

365004

KPYK1
Pyruvate kinase 1

1

3

High-throughput

0.437

High

444478

DED1
ATP-dependent RNA helicase DED1

1

6

High-throughput

0.437

High

558666

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

649597

KCC2
Calcium/calmodulin-dependent protein kinase II

1

7

High-throughput

0.437

High

706678

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

734648

IMB3
Importin subunit beta-3

1

11

High-throughput

0.437

High

737816

HOG1
Mitogen-activated protein kinase HOG1

1

8

High-throughput

0.437

High

755070

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

755071

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

755073

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

755075

SRPB
Signal recognition particle receptor subunit beta

1

4

High-throughput

0.437

High

755089

RPN1
26S proteasome regulatory subunit RPN1

1

7

High-throughput

0.437

High

755094

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

16

High-throughput

0.437

High

755098

DHH1
ATP-dependent RNA helicase DHH1

1

12

High-throughput

0.437

High

755110

TM108
Protein TMA108

1

6

High-throughput

0.437

High

755115

RLP7
Ribosome biogenesis protein RLP7

1

6

High-throughput

0.437

High

755130

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.437

High

755134

PESC
Pescadillo homolog

1

4

High-throughput

0.437

High

755137

YN8S
Phospholipid-transporting ATPase accessory subunit CRF1

1

1

High-throughput

0.437

High

755149

ACT
Actin

1

4

Small-scale

0.437

High

755152

CDC14
Tyrosine-protein phosphatase CDC14

1

20

Small-scale

0.437

High

755159

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.437

High

755164

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.437

High

755178

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

755186

SGO1
Shugoshin

1

2

High-throughput

0.437

High

755189

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.437

High

454095

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

653848

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

746027

YME2
Mitochondrial escape protein 2

1

0

High-throughput

0.426

High

755099

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

755112

SHQ1
Protein SHQ1

1

0

High-throughput

0.426

High

755136

MPA43
Protein MPA43

1

0

High-throughput

0.426

High

755173

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.426

High

755103

RBG1
Ribosome-interacting GTPase 1

1

9

High-throughput

0.417

High

358177

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.407

High

364453

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.407

High

419682

H2A2
Histone H2A.2

1

6

High-throughput

0.407

High

427208

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

592151

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.407

High

597725

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.407

High

613849

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.407

High

628255

ZRC1
Vacuolar zinc transporter ZRC1

1

4

High-throughput

0.407

High

672006

MSH3
DNA mismatch repair protein MSH3

1

2

High-throughput

0.407

High

721597

RENT1
ATP-dependent helicase NAM7

1

4

High-throughput

0.407

High

740249

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.407

High

751366

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

High-throughput

0.407

High

752953

IXR1
Intrastrand cross-link recognition protein

1

6

High-throughput

0.407

High

755085

SRP68
Signal recognition particle subunit SRP68

1

3

High-throughput

0.407

High

755088

DBP8
ATP-dependent RNA helicase DBP8

1

11

High-throughput

0.407

High

755090

CIC1
Proteasome-interacting protein CIC1

1

3

High-throughput

0.407

High

755095

AKR1
Palmitoyltransferase AKR1

1

12

High-throughput

0.407

High

755096

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

755114

ICE2
Protein ICE2

1

1

High-throughput

0.407

High

755139

NOG2
Nucleolar GTP-binding protein 2

1

5

High-throughput

0.407

High

755147

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.407

High

755154

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.407

High

755155

NOG1
Nucleolar GTP-binding protein 1

1

6

High-throughput

0.407

High

755158

SVL3
Styryl dye vacuolar localization protein 3

1

1

High-throughput

0.407

High

755160

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

3

High-throughput

0.407

High

755167

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

10

High-throughput

0.407

High

755170

UTP15
U3 small nucleolar RNA-associated protein 15

1

8

High-throughput

0.407

High

755174

RCO1
Transcriptional regulatory protein RCO1

1

10

High-throughput

0.407

High

755176

MRD1
Multiple RNA-binding domain-containing protein 1

1

7

High-throughput

0.407

High

755182

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.407

High

755183

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.407

High

755184

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.407

High

755196

IES3
Ino eighty subunit 3

1

1

High-throughput

0.407

High

755197

ARP7
Actin-related protein 7

1

5

High-throughput

0.407

High

755200

NOP58
Nucleolar protein 58

1

8

High-throughput

0.407

High

755201

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.407

High

755202

H2AZ
Histone H2A.Z

1

8

High-throughput

0.407

High

755102

ECM1
Shuttling pre-60S factor ECM1

2

0

High-throughput

0.307

High

755128

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

755157

COFI
Cofilin

1

0

High-throughput

0.279

Low

755193

UPPS
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

755078

SPC34
DASH complex subunit SPC34

1

0

High-throughput

0.269

Low

755077

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

755107

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.249

Low

755124

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

High-throughput

0.249

Low

755203

ATG44
Mitofissin

1

0

High-throughput

0.249

Low

755205

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

755175

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.238

Low

646725

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

703803

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

755079

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.232

Low

755127

YJY2
Uncharacterized protein YJR012C

1

0

High-throughput

0.232

Low

755140

CAF40
Protein CAF40

1

0

High-throughput

0.232

Low

755144

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

755148

DOS2
Protein DOS2

1

0

High-throughput

0.232

Low

755150

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.232

Low

755162

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.232

Low

755179

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.232

Low

755188

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025