Protein: GCN20
Protein GCN20 (General control non-derepressible protein 20)

Gene: GCN20
Organism: Saccharomyces cerevisiae S288C
Interactions: 127
UniProt ID: P43535

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0006448 - regulation of translational elongation
GO:0016887 - ATP hydrolysis activity
GO:0022626 - cytosolic ribosome
GO:0031369 - translation initiation factor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584369

GCN2
eIF-2-alpha kinase GCN2

2

1

Small-scale

0.812

High

755119

GCN1
eIF-2-alpha kinase activator GCN1

8

9

Small-scale

0.756

High

642409

MCK1
Protein kinase MCK1

1

1

High-throughput

0.647

High

801855

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.647

High

597491

EF3A
Elongation factor 3A

1

6

High-throughput

0.618

High

802562

SYNC
Asparagine--tRNA ligase, cytoplasmic

2

6

High-throughput

0.611

High

849571

RUVB2
RuvB-like protein 2

2

6

High-throughput

0.611

High

675343

RAD51
DNA repair protein RAD51

2

1

High-throughput

0.588

High

646138

NPR1
Nitrogen permease reactivator protein

1

4

High-throughput

0.575

High

849560

HRK1
Serine/threonine-protein kinase HRK1

1

2

High-throughput

0.575

High

536035

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

1

High-throughput

0.567

High

449352

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

2

0

High-throughput

0.563

High

545285

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.552

High

470548

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

6

High-throughput

0.489

High

813288

FHP
Flavohemoprotein

1

2

High-throughput

0.489

High

836752

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

849527

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.489

High

849537

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

849545

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.489

High

849551

GCN5
Histone acetyltransferase GCN5

1

8

High-throughput

0.489

High

750706

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.481

High

802516

SYSM
Serine--tRNA ligase, mitochondrial

1

6

High-throughput

0.481

High

392912

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

416252

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

579592

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

581873

SYKC
Lysine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

679806

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

727118

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

802644

YHI0
Putative proline--tRNA ligase YHR020W

1

6

High-throughput

0.479

High

807193

IF1A
Eukaryotic translation initiation factor 1A

1

3

High-throughput

0.479

High

849532

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

849553

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.479

High

849569

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

849540

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.470

High

849563

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

394666

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

524300

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

526976

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

597744

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

676096

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

713274

MCM5
Minichromosome maintenance protein 5

1

7

High-throughput

0.445

High

741804

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

752400

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

802875

DBP8
ATP-dependent RNA helicase DBP8

1

6

High-throughput

0.445

High

804241

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

819053

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

849536

DBP6
ATP-dependent RNA helicase DBP6

1

3

High-throughput

0.445

High

758106

CASP
Protein CASP

1

4

High-throughput

0.439

High

777066

BDF1
Bromodomain-containing factor 1

1

9

High-throughput

0.439

High

804902

LAM4
Membrane-anchored lipid-binding protein LAM4

1

1

High-throughput

0.439

High

817731

TSC11
Target of rapamycin complex 2 subunit TSC11

1

3

High-throughput

0.439

High

829779

MAD1
Spindle assembly checkpoint component MAD1

1

3

High-throughput

0.439

High

849535

YG3A
Uncharacterized protein YGR130C

1

2

High-throughput

0.439

High

149826

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

382165

H4
Histone H4

1

1

High-throughput

0.437

High

410196

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

435171

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

441977

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

503106

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

512503

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

514689

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.437

High

558773

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

594427

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

647147

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

670850

SIS1
Protein SIS1

1

7

High-throughput

0.437

High

672681

BPH1
Beige protein homolog 1

1

1

High-throughput

0.437

High

689523

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.437

High

707410

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

779267

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

806747

RPN10
26S proteasome regulatory subunit RPN10

1

3

High-throughput

0.437

High

812412

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

826588

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.437

High

849526

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.437

High

849531

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.437

High

849543

H3
Histone H3

1

7

High-throughput

0.437

High

849544

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

849546

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

849548

ESP1
Separin

1

2

High-throughput

0.437

High

849552

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

849561

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

849562

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

849572

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.437

High

672020

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.426

High

849529

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.426

High

554356

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.407

High

736858

APE2
Aminopeptidase 2, mitochondrial

1

4

High-throughput

0.407

High

812236

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.407

High

849530

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.407

High

849538

HCH1
Hsp90 co-chaperone HCH1

1

3

High-throughput

0.407

High

849539

CNM67
Chaotic nuclear migration protein 67

1

2

High-throughput

0.407

High

849549

SVL3
Styryl dye vacuolar localization protein 3

1

1

High-throughput

0.407

High

849556

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

849557

UBX5
UBX domain-containing protein 5

1

1

High-throughput

0.407

High

849558

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.407

High

849565

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.407

High

849568

IES3
Ino eighty subunit 3

1

1

High-throughput

0.407

High

751706

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

2

0

High-throughput

0.307

High

790210

GLYC
Serine hydroxymethyltransferase, cytosolic

2

0

High-throughput

0.307

High

486480

TBA3
Tubulin alpha-3 chain

1

0

High-throughput

0.279

Low

550590

SST2
Protein SST2

1

0

High-throughput

0.279

Low

600695

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.279

Low

779420

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

849559

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.279

Low

803049

EFM1
Protein-lysine N-methyltransferase EFM1

1

0

High-throughput

0.269

Low

736993

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

749682

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

816687

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.251

Low

849533

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.251

Low

849547

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

849555

ARR1
Arsenical-resistance protein ARR1

1

0

High-throughput

0.251

Low

795053

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

849554

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

849566

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.249

Low

849567

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

646733

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

699509

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.232

Low

809154

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.232

Low

815935

PP2C2
Protein phosphatase 2C homolog 2

1

0

High-throughput

0.232

Low

816821

FMP52
Protein FMP52, mitochondrial

1

0

High-throughput

0.232

Low

825864

VHR1
Transcription factor VHR1

1

0

High-throughput

0.232

Low

849528

CDT1
Cell division cycle protein CDT1

1

0

High-throughput

0.232

Low

849534

MDS3
Negative regulator of sporulation MDS3

1

0

High-throughput

0.232

Low

849541

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.232

Low

849542

SIW14
Inositol diphosphatase SIW14

1

0

High-throughput

0.232

Low

849550

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.232

Low

849564

NMD4
Nonsense-mediated decay protein 4

1

0

High-throughput

0.232

Low

849570

ARP7
Actin-related protein 7

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025