HitPredict

Interactor 1: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	28514442, 29802200, 33961781, 18281698
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1, RRM_1~U1snRNP70_N
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 582
+	Hs
		516541 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1116542 PABP3_HUMAN (4-361): 3.46e-50: 181: 11.86		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		516689 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11
+	Hs
		516495 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516339 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		516568 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		516616 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		403059 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		442125 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		441852 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		442260 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		516635 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		442467 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		442353 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Mm
		665745 PABP1_MOUSE (4-361): 4.42e-53: 189: 11.08		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Mm
		857334 RU17_MOUSE (1-437): 1.33e-49: 176: 89.78		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		516561 PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		442250 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		442183 RU17_HUMAN (1-437): 8.99e-46: 165: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50