Protein: SVIL
Supervillin (Archvillin) (p205/p250)

Gene: SVIL
Organism: Homo sapiens
Interactions: 238
UniProt ID: O95425

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

336383

ACTB
Actin, cytoplasmic 1

2

20

Small-scale

0.754

High

336354

TMOD1
Tropomodulin-1

2

13

High-throughput

0.737

High

336497

TMOD3
Tropomodulin-3

2

12

High-throughput

0.726

High

336373

CAZA2
F-actin-capping protein subunit alpha-2

5

4

High-throughput

0.716

High

336385

ARP2
Actin-related protein 2

1

20

High-throughput

0.691

High

336374

CAPZB
F-actin-capping protein subunit beta

3

3

High-throughput

0.662

High

336489

ANLN
Anillin

3

3

High-throughput

0.656

High

277871

SH3L1
Adapter SH3BGRL

3

2

High-throughput

0.650

High

336335

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.643

High

336380

DAPK1
Death-associated protein kinase 1

2

9

High-throughput

0.628

High

336364

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

5

High-throughput

0.611

High

336379

CAZA1
F-actin-capping protein subunit alpha-1

2

4

High-throughput

0.611

High

336435

DREB
Drebrin

2

3

High-throughput

0.601

High

336312

ESR1
Estrogen receptor

2

12

Small-scale

0.586

High

336347

FLNA
Filamin-A

2

7

Small-scale

0.586

High

336426

KIF14
Kinesin-like protein KIF14

2

7

Small-scale

0.586

High

336507

LIMA1
LIM domain and actin-binding protein 1

2

3

Small-scale

0.586

High

336338

EZRI
Ezrin

2

2

High-throughput

0.584

High

336420

DX39B
Spliceosome RNA helicase DDX39B

2

2

Small-scale

0.584

High

336454

NIN
Ninein

2

13

High-throughput

0.584

High

336352

1433T
14-3-3 protein theta

2

10

High-throughput

0.571

High

336356

1433B
14-3-3 protein beta/alpha

2

10

High-throughput

0.571

High

336428

KPCD1
Serine/threonine-protein kinase D1

2

4

High-throughput

0.571

High

336466

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.561

High

336336

KPYM
Pyruvate kinase PKM

2

0

High-throughput

0.559

High

287836

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

High-throughput

0.536

High

323019

WDR47
WD repeat-containing protein 47

1

6

High-throughput

0.536

High

336306

CHK2
Serine/threonine-protein kinase Chk2

1

4

High-throughput

0.536

High

336327

FBSP1
F-box/SPRY domain-containing protein 1

1

6

High-throughput

0.536

High

336350

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.536

High

336361

MYH9
Myosin-9

1

5

High-throughput

0.536

High

336362

ADDA
Alpha-adducin

1

1

High-throughput

0.536

High

336363

MYH11
Myosin-11

1

5

High-throughput

0.536

High

336375

NEST
Nestin

1

11

High-throughput

0.536

High

336384

DEST
Destrin

1

1

High-throughput

0.536

High

336386

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

336403

CENPE
Centromere-associated protein E

1

2

High-throughput

0.536

High

336411

CALD1
Caldesmon

1

19

High-throughput

0.536

High

336432

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

2

High-throughput

0.536

High

336445

L2GL2
LLGL scribble cell polarity complex component 2

1

2

High-throughput

0.536

High

336446

KLC3
Kinesin light chain 3

1

1

High-throughput

0.536

High

336449

PAXI1
PAX-interacting protein 1

1

3

High-throughput

0.536

High

336452

ABRA
Actin-binding Rho-activating protein

1

2

High-throughput

0.536

High

336455

DYLT5
Dynein light chain Tctex-type 5

1

1

High-throughput

0.536

High

336457

ARRD4
Arrestin domain-containing protein 4

1

7

High-throughput

0.536

High

336459

TBCK
TBC domain-containing protein kinase-like protein

1

6

High-throughput

0.536

High

336460

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.536

High

336465

MY18A
Unconventional myosin-XVIIIa

1

10

High-throughput

0.536

High

336470

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

336475

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.536

High

336480

HDAC8
Histone deacetylase 8

1

3

High-throughput

0.536

High

336490

MYO5C
Unconventional myosin-Vc

1

7

High-throughput

0.536

High

336492

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.536

High

336511

MYH13
Myosin-13

1

5

High-throughput

0.536

High

336329

ANDR
Androgen receptor

1

10

Small-scale

0.527

High

336317

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.515

High

336318

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

336341

H15
Histone H1.5

1

1

High-throughput

0.515

High

336382

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.515

High

336438

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

336451

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.515

High

336467

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.515

High

336503

SPAST
Spastin

1

4

High-throughput

0.515

High

66784

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

277306

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.513

High

336322

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

336413

MALL
MAL-like protein

1

0

High-throughput

0.513

High

336431

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

336461

JPH3
Junctophilin-3

1

0

High-throughput

0.513

High

336495

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.513

High

336514

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

336346

NEBU
Nebulin

1

5

Small-scale

0.506

High

336398

DYLT1
Dynein light chain Tctex-type 1

1

1

Small-scale

0.501

High

336430

TRIP6
Thyroid receptor-interacting protein 6

1

4

Small-scale

0.501

High

336316

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.493

High

336393

H4
Histone H4

1

0

High-throughput

0.493

High

336405

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.493

High

336437

H31T
Histone H3.1t

1

0

High-throughput

0.493

High

336499

CFA97
Cilia- and flagella-associated protein 97

1

1

High-throughput

0.489

High

124182

HAX1
HCLS1-associated protein X-1

1

1

Small-scale

0.481

High

224071

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

3

Small-scale

0.481

High

276259

HMMR
Hyaluronan mediated motility receptor

1

15

Small-scale

0.481

High

336310

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

Small-scale

0.481

High

336315

GCR
Glucocorticoid receptor

1

11

Small-scale

0.481

High

336319

K1C18
Keratin, type I cytoskeletal 18

1

2

Small-scale

0.481

High

336320

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.481

High

336365

PPARG
Peroxisome proliferator-activated receptor gamma

1

11

Small-scale

0.481

High

336376

CENPF
Centromere protein F

1

18

Small-scale

0.481

High

336406

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.481

High

336419

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

4

Small-scale

0.481

High

336422

KIF22
Kinesin-like protein KIF22

1

2

Small-scale

0.481

High

336440

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

5

Small-scale

0.481

High

336441

ODFP2
Outer dense fiber protein 2

1

9

Small-scale

0.481

High

336442

SPD2A
SH3 and PX domain-containing protein 2A

1

1

Small-scale

0.481

High

336500

STAR9
StAR-related lipid transfer protein 9

1

5

Small-scale

0.481

High

72697

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

14

Small-scale

0.479

High

123538

MYO1C
Unconventional myosin-Ic

1

14

High-throughput

0.479

High

156805

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

217660

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

224568

ACTN4
Alpha-actinin-4

1

5

Small-scale

0.479

High

247580

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

299001

FLOT1
Flotillin-1

1

3

Small-scale

0.479

High

323063

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

330535

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

336303

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.479

High

336307

FOS
Protein c-Fos

1

5

High-throughput

0.479

High

336308

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

336309

TNFA
Tumor necrosis factor

1

1

High-throughput

0.479

High

336313

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

336321

LYN
Tyrosine-protein kinase Lyn

1

4

Small-scale

0.479

High

336323

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

336326

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

336330

H14
Histone H1.4

1

1

High-throughput

0.479

High

336331

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

336332

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

336333

ACTN1
Alpha-actinin-1

1

5

Small-scale

0.479

High

336334

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

336340

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

336344

ML12A
Myosin regulatory light chain 12A

1

3

Small-scale

0.479

High

336345

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

336349

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

336351

STOM
Stomatin

1

2

Small-scale

0.479

High

336353

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

336357

1433S
14-3-3 protein sigma

1

10

High-throughput

0.479

High

336358

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

336360

RADI
Radixin

1

2

High-throughput

0.479

High

336368

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

336372

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

336377

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.479

High

336381

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

336387

1433G
14-3-3 protein gamma

1

10

High-throughput

0.479

High

336388

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.479

High

336389

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

336390

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.479

High

336394

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

Small-scale

0.479

High

336397

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.479

High

336400

VIGLN
Vigilin

1

2

High-throughput

0.479

High

336402

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

Small-scale

0.479

High

336404

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

336409

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

336410

1433F
14-3-3 protein eta

1

10

High-throughput

0.479

High

336418

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

Small-scale

0.479

High

336421

FLOT2
Flotillin-2

1

3

Small-scale

0.479

High

336425

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

336427

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

336433

ZYX
Zyxin

1

2

High-throughput

0.479

High

336436

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

336439

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

336447

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

336448

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

11

High-throughput

0.479

High

336453

SYNPO
Synaptopodin

1

3

High-throughput

0.479

High

336458

BICD2
Protein bicaudal D homolog 2

1

13

High-throughput

0.479

High

336463

SSH1
Protein phosphatase Slingshot homolog 1

1

3

High-throughput

0.479

High

336464

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

336468

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

336472

ASB16
Ankyrin repeat and SOCS box protein 16

1

8

High-throughput

0.479

High

336476

MEP50
Methylosome protein WDR77

1

4

High-throughput

0.479

High

336477

OVOL2
Transcription factor Ovo-like 2

1

7

Small-scale

0.479

High

336479

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

336483

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

336484

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

336486

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

336488

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

336491

PDLI7
PDZ and LIM domain protein 7

1

3

High-throughput

0.479

High

336502

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

336504

ZO2
Tight junction protein 2

1

1

High-throughput

0.479

High

336506

TES
Testin

1

3

High-throughput

0.479

High

336509

HOOK1
Protein Hook homolog 1

1

14

High-throughput

0.479

High

336510

MYH2
Myosin-2

1

5

Small-scale

0.479

High

336515

NINL
Ninein-like protein

1

10

High-throughput

0.479

High

72402

MI4GD
MIF4G domain-containing protein

1

0

Small-scale

0.460

High

336348

NDKB
Nucleoside diphosphate kinase B

1

0

Small-scale

0.460

High

336371

ATRX
Transcriptional regulator ATRX

1

0

Small-scale

0.460

High

336415

CENPR
Centromere protein R

1

0

Small-scale

0.460

High

336501

UXT
Protein UXT

1

0

Small-scale

0.460

High

336513

MRTFB
Myocardin-related transcription factor B

1

0

Small-scale

0.460

High

178460

TBX3
T-box transcription factor TBX3

1

0

High-throughput

0.458

High

336304

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

336324

VIME
Vimentin

1

0

Small-scale

0.458

High

336337

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.458

High

336343

VGFR1
Vascular endothelial growth factor receptor 1

1

0

High-throughput

0.458

High

336366

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

336367

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

336378

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

336391

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

336392

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

336396

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

0

Small-scale

0.458

High

336401

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

336412

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.458

High

336417

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

336444

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

336456

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.458

High

336462

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.458

High

336471

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

336493

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

336498

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

336505

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.458

High

336508

XPO7
Exportin-7

1

0

High-throughput

0.458

High

336517

GPSM3
G-protein-signaling modulator 3

1

0

Small-scale

0.458

High

336423

MYPC3
Myosin-binding protein C, cardiac-type

1

2

Small-scale

0.457

High

254700

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

336311

TNNC2
Troponin C, skeletal muscle

1

1

High-throughput

0.445

High

336359

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

336369

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.445

High

336395

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.445

High

336416

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

336434

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

High-throughput

0.445

High

336443

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.445

High

336450

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

336474

ZBT18
Zinc finger and BTB domain-containing protein 18

1

6

High-throughput

0.445

High

336482

TOLIP
Toll-interacting protein

1

1

High-throughput

0.445

High

336408

LMNB2
Lamin-B2

1

2

Small-scale

0.439

High

336487

PCX3
Pecanex-like protein 3

1

1

Small-scale

0.439

High

336342

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.438

High

336370

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

0

Small-scale

0.438

High

105021

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

336429

SYCP1
Synaptonemal complex protein 1

1

13

High-throughput

0.437

High

336494

DJC11
DnaJ homolog subfamily C member 11

1

3

High-throughput

0.437

High

336328

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

336355

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

0

High-throughput

0.426

High

336481

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

336496

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

336512

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.407

High

336516

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.282

High

317054

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

High-throughput

0.279

Low

336305

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

336399

CXCL6
C-X-C motif chemokine 6

1

0

High-throughput

0.279

Low

336414

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

336469

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

336424

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

336473

MPP9
M-phase phosphoprotein 9

1

0

Small-scale

0.251

Low

336478

KIFC3
Kinesin-like protein KIFC3

1

0

Small-scale

0.251

Low

336314

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.249

Low

336325

PAEP
Glycodelin

1

0

High-throughput

0.249

Low

336339

GNS
N-acetylglucosamine-6-sulfatase

1

0

High-throughput

0.249

Low

336407

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

336485

GAPR1
Golgi-associated plant pathogenesis-related protein 1

1

0

Small-scale

0.249

Low

87289

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025