HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11071635
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 481
+	Hs
		523124 SRC_HUMAN (1-524): 0: 582: 54.51		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433460 YES_HUMAN (1-524): 0: 570: 56.77		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433966 LYN_HUMAN (22-526): 0: 554: 70.70		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		454844 FGR_HUMAN (22-524): 0: 552: 55.62		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		639441 LYN_MOUSE (22-526): 0: 555: 70.70		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		250949 SRC_MOUSE (1-524): 0: 585: 55.56		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235040 SRC_HUMAN (1-524): 0: 582: 54.51		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235035 LCK_HUMAN (23-526): 0: 581: 64.89		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235037 YES_HUMAN (1-524): 0: 570: 56.77		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235036 FYN_HUMAN (22-524): 0: 564: 57.79		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		250950 LYN_MOUSE (22-526): 0: 555: 70.70		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		151689 LCK_HUMAN (23-526): 0: 581: 64.89		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		151692 LYN_HUMAN (22-526): 0: 554: 70.70		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		412057 FYN_HUMAN (22-524): 0: 564: 57.79		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		207290 HCK_HUMAN (1-526): 0: 635: 100.00		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Mm
		639440 LYN_MOUSE (22-526): 0: 555: 70.70		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Mm
		403453 SRC_MOUSE (1-524): 0: 585: 55.56		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Hs
		411805 LCK_HUMAN (23-526): 0: 581: 64.89		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		433914 LYN_HUMAN (22-526): 0: 554: 70.70		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Dm
		1360394 SRC42_DROME (11-524): 0: 538: 51.24		Q9W3R6_DROME (1-256): 8.47e-59: 206: 25.75