HitPredict

Interactor 1: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12029088
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 639
+	Hs
		412426 FYN_HUMAN (22-524): 0: 564: 57.79		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		442869 HCK_HUMAN (1-526): 0: 635: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		523104 SRC_HUMAN (1-524): 0: 582: 54.51		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		411817 LCK_HUMAN (23-526): 0: 581: 64.89		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		412296 FYN_HUMAN (22-524): 0: 564: 57.79		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		433938 LYN_HUMAN (22-526): 0: 554: 70.70		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		454842 FGR_HUMAN (22-524): 0: 552: 55.62		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		522887 SRC_HUMAN (1-524): 0: 582: 54.51		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		763393 FYN_MOUSE (22-524): 0: 564: 57.60		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		209001 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		275157 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Mm
		763403 FYN_MOUSE (22-524): 0: 564: 57.60		NCK1_MOUSE (113-378): 6.4e-21: 97.3: 14.24
+	Hs
		411986 FYN_HUMAN (22-524): 0: 564: 57.79		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		789054 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		433781 LYN_HUMAN (22-526): 0: 554: 70.70		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		433807 LYN_HUMAN (22-526): 0: 554: 70.70		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		557630 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		298959 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		235483 ABL2_HUMAN (17-523): 5.55e-166: 503: 38.06		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Hs
		235462 ABL1_HUMAN (47-523): 1.77e-166: 502: 39.38		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28