Protein: THB
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

Gene: THB, THRB
Organism: Homo sapiens
Interactions: 66
UniProt ID: P10828

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533320

RXRA
Retinoic acid receptor RXR-alpha

9

20

Small-scale

0.968

High

533350

NCOA1
Nuclear receptor coactivator 1

8

20

Small-scale

0.963

High

533370

NCOA3
Nuclear receptor coactivator 3

3

20

Small-scale

0.861

High

533315

THB
Thyroid hormone receptor beta

3

19

Small-scale

0.845

High

533346

NCOA2
Nuclear receptor coactivator 2

3

20

Small-scale

0.840

High

278217

NCOR1
Nuclear receptor corepressor 1

9

20

Small-scale

0.752

High

533369

NCOR2
Nuclear receptor corepressor 2

8

20

Small-scale

0.747

High

522765

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.740

High

533344

NCOA6
Nuclear receptor coactivator 6

5

20

Small-scale

0.704

High

533334

PRS8
26S proteasome regulatory subunit 8

3

20

Small-scale

0.639

High

533332

ACTB
Actin, cytoplasmic 1

2

9

High-throughput

0.628

High

533366

PDLI7
PDZ and LIM domain protein 7

2

14

High-throughput

0.628

High

533324

RXRB
Retinoic acid receptor RXR-beta

1

18

High-throughput

0.621

High

533327

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.621

High

533330

IMA5
Importin subunit alpha-5

1

7

Small-scale

0.618

High

261362

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

20

Small-scale

0.602

High

413070

P53
Cellular tumor antigen p53

2

6

Small-scale

0.595

High

533356

ROBO4
Roundabout homolog 4

1

6

Small-scale

0.579

High

533335

ACTA
Actin, aortic smooth muscle

2

8

High-throughput

0.574

High

533351

ACTBL
Beta-actin-like protein 2

2

9

High-throughput

0.574

High

533360

RANB9
Ran-binding protein 9

1

15

Small-scale

0.573

High

188156

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.561

High

533322

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.561

High

533337

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

Small-scale

0.561

High

533367

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

20

Small-scale

0.561

High

533348

TRIP4
Activating signal cointegrator 1

1

5

Small-scale

0.527

High

533365

BRD8
Bromodomain-containing protein 8

1

20

Small-scale

0.527

High

533357

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.518

High

533316

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

Small-scale

0.501

High

533319

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

9

Small-scale

0.501

High

533323

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

11

Small-scale

0.501

High

533326

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

7

Small-scale

0.501

High

533336

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.501

High

533340

MED21
Mediator of RNA polymerase II transcription subunit 21

1

3

Small-scale

0.501

High

533342

C1D
Nuclear nucleic acid-binding protein C1D

1

1

Small-scale

0.501

High

533352

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

3

Small-scale

0.501

High

533354

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

20

Small-scale

0.501

High

533361

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

Small-scale

0.501

High

533363

ANM1
Protein arginine N-methyltransferase 1

1

18

Small-scale

0.501

High

373743

RASN
GTPase NRas

1

4

High-throughput

0.489

High

533368

DYN3
Dynamin-3

1

2

High-throughput

0.489

High

533328

NRIP1
Nuclear receptor-interacting protein 1

1

16

High-throughput

0.481

High

533333

CSN2
COP9 signalosome complex subunit 2

1

6

Small-scale

0.481

High

533341

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

5

High-throughput

0.481

High

533358

NRBF2
Nuclear receptor-binding factor 2

1

3

Small-scale

0.481

High

533359

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

486892

PARP1
Poly [ADP-ribose] polymerase 1

1

11

Small-scale

0.479

High

533317

XRCC6
X-ray repair cross-complementing protein 6

1

14

Small-scale

0.479

High

533318

XRCC5
X-ray repair cross-complementing protein 5

1

14

Small-scale

0.479

High

533321

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

533325

HSP74
Heat shock 70 kDa protein 4

1

18

Small-scale

0.479

High

533329

DNLI3
DNA ligase 3

1

3

Small-scale

0.479

High

533331

ANM2
Protein arginine N-methyltransferase 2

1

18

Small-scale

0.479

High

533339

GPS2
G protein pathway suppressor 2

1

4

Small-scale

0.479

High

533343

SMC1A
Structural maintenance of chromosomes protein 1A

1

7

Small-scale

0.479

High

533345

IMB1
Importin subunit beta-1

1

3

Small-scale

0.479

High

533347

MED1
Mediator of RNA polymerase II transcription subunit 1

1

20

Small-scale

0.479

High

533355

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

533364

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

20

Small-scale

0.479

High

258065

IF2P
Eukaryotic translation initiation factor 5B

1

9

High-throughput

0.470

High

533349

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.460

High

533362

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.460

High

63944

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

Small-scale

0.457

High

533338

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

533353

MED25
Mediator of RNA polymerase II transcription subunit 25

1

7

Small-scale

0.457

High


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Last updated: 11Aug2025