Protein: PSA4
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)

Gene: PSA4, PRE6
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: P40303

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604803

PSB4
Proteasome subunit beta type-4

19

20

Small-scale

0.987

High

675422

PSB5
Proteasome subunit beta type-5

8

20

Small-scale

0.963

High

597328

PSA1
Proteasome subunit alpha type-1

7

20

Small-scale

0.962

High

619476

PSA2
Proteasome subunit alpha type-2

7

18

High-throughput

0.962

High

597248

PSA7
Probable proteasome subunit alpha type-7

6

19

Small-scale

0.943

High

771369

BLM10
Proteasome activator BLM10

6

7

Small-scale

0.935

High

619364

PSA3
Proteasome subunit alpha type-3

5

19

Small-scale

0.922

High

771331

PSA6
Proteasome subunit alpha type-6

5

19

High-throughput

0.922

High

689186

PSA5
Proteasome subunit alpha type-5

5

19

Small-scale

0.912

High

619977

PSB6
Proteasome subunit beta type-6

4

18

High-throughput

0.896

High

675474

PSB7
Proteasome subunit beta type-7

4

19

Small-scale

0.892

High

747929

UMP1
Proteasome maturation factor UMP1

4

2

Small-scale

0.881

High

632491

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.855

High

751166

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.855

High

771364

PSA4
Proteasome subunit alpha type-4

3

17

Small-scale

0.847

High

703908

PRS7
26S proteasome regulatory subunit 7 homolog

3

20

Small-scale

0.847

High

771392

POC4
Proteasome chaperone 4

2

1

Small-scale

0.789

High

703804

PRS6B
26S proteasome regulatory subunit 6B homolog

2

20

High-throughput

0.789

High

771394

RPN6
26S proteasome regulatory subunit RPN6

2

20

High-throughput

0.789

High

625941

PSB2
Proteasome subunit beta type-2

2

20

High-throughput

0.776

High

703643

PRS6A
26S proteasome regulatory subunit 6A

2

20

High-throughput

0.754

High

771370

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

10

20

Small-scale

0.751

High

705243

HSP78
Heat shock protein 78, mitochondrial

2

0

High-throughput

0.699

High

753403

ECM29
Proteasome component ECM29

4

10

Small-scale

0.686

High

771393

RPN5
26S proteasome regulatory subunit RPN5

4

20

Small-scale

0.686

High

756941

RPN10
26S proteasome regulatory subunit RPN10

3

11

High-throughput

0.662

High

693311

RPN2
26S proteasome regulatory subunit RPN2

3

20

Small-scale

0.660

High

771389

RPN8
26S proteasome regulatory subunit RPN8

3

18

Small-scale

0.656

High

771387

POC3
Proteasome chaperone 3

1

1

Small-scale

0.647

High

636642

CDC48
Cell division control protein 48

1

8

High-throughput

0.618

High

731549

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.618

High

771365

PRS4
26S proteasome regulatory subunit 4 homolog

1

20

High-throughput

0.618

High

771373

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

771378

PRS8
26S proteasome regulatory subunit 8 homolog

1

20

High-throughput

0.618

High

753833

RPN1
26S proteasome regulatory subunit RPN1

2

20

High-throughput

0.611

High

766857

RPN3
26S proteasome regulatory subunit RPN3

2

8

High-throughput

0.611

High

771383

RPN9
26S proteasome regulatory subunit RPN9

2

11

High-throughput

0.611

High

771385

RPN7
26S proteasome regulatory subunit RPN7

2

20

High-throughput

0.611

High

687951

IMB3
Importin subunit beta-3

2

0

High-throughput

0.595

High

691477

RPN12
26S proteasome regulatory subunit RPN12

2

4

Small-scale

0.584

High

754127

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.568

High

771384

POC1
Proteasome chaperone 1

1

1

High-throughput

0.553

High

491397

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.552

High

511521

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.552

High

694805

HSP7F
Heat shock protein homolog SSE1

2

10

High-throughput

0.552

High

635586

PWP2
Periodic tryptophan protein 2

2

2

High-throughput

0.537

High

431137

CDC4
Cell division control protein 4

1

12

Small-scale

0.536

High

771374

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

771376

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

636228

FUB1
Silencing boundary-establishment protein FUB1

2

1

Small-scale

0.533

High

618841

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

655035

CIN8
Kinesin-like protein CIN8

1

5

High-throughput

0.515

High

771367

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

1

High-throughput

0.515

High

730984

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

771386

PIN3
[PSI+] inducibility protein 3

1

2

High-throughput

0.508

High

713696

NOT4
General negative regulator of transcription subunit 4

1

3

High-throughput

0.501

High

141852

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.479

High

407089

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

413539

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

543841

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

628124

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

662383

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

688268

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

697091

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

698826

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

703158

UFD4
Ubiquitin fusion degradation protein 4

1

20

Small-scale

0.479

High

730817

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

771366

MLP2
Protein MLP2

1

4

High-throughput

0.479

High

771371

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

10

High-throughput

0.479

High

771375

H3
Histone H3

1

3

High-throughput

0.479

High

771377

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

771381

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

771390

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

771395

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

771396

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

141366

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

358095

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

425986

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

566183

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

631914

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

771372

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

771382

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

771388

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.458

High

771391

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

494109

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

768568

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

765174

PAC2
Protein PAC2

1

8

Small-scale

0.437

High

771379

VPS60
Vacuolar protein-sorting-associated protein 60

1

4

Small-scale

0.437

High

771368

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

587312

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.269

Low

771380

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.261

Low

697151

ANP1
Mannan polymerase II complex ANP1 subunit

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024