HitPredict

Interactor 1: MEC3 (P09088)
Mechanosensory protein 3
Gene: mec-3

Interactor 2: HMBX1 (Q9TYT0)
Homeobox-containing protein 1
Gene: hmbx-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 321 Ce			1 424
+	Ce
		106229 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		VAB3_CAEEL (94-420): 2.5e-47: 170: 15.18
+	Hs
		641346 LHX2_HUMAN (6-311): 4.03e-63: 207: 21.86		PAX6_HUMAN (94-410): 9.34e-45: 162: 12.10
+	Ce
		105793 MEC3_CAEEL (1-321): 1.79e-71: 226: 100.00		PAX3H_CAEEL (93-335): 8.29e-35: 132: 11.07
+	Hs
		638516 RBTN1_HUMAN (9-140): 4.74e-39: 136: 26.47		HMBX1_HUMAN (3-339): 1.48e-64: 214: 26.08
+	Mm
		192277 LMX1B_MOUSE (1-316): 4.9e-58: 193: 21.84		ALX4_MOUSE (39-397): 3.35e-41: 152: 12.43
+	Ce
		104761 LIM7_CAEEL (16-288): 3.64e-46: 163: 23.73		VAB3_CAEEL (94-420): 2.5e-47: 170: 15.18
+	Hs
		686548 LHX1_HUMAN (28-312): 2.09e-60: 200: 31.93		OTX2_HUMAN (209-421): 1.98e-29: 117: 19.25
+	Hs
		238108 LMX1B_HUMAN (1-316): 6.62e-58: 193: 21.84		PAX2_HUMAN (94-392): 2.24e-30: 123: 8.45
+	Hs
		1255789 LMX1A_HUMAN (1-296): 1.39e-56: 189: 22.30		LMX1A_HUMAN (121-423): 7.2e-31: 124: 11.22
+	Hs
		899927 ISL1_HUMAN (27-288): 1.71e-48: 167: 24.15		LMX1A_HUMAN (121-423): 7.2e-31: 124: 11.22
+	Hs
		1156033 LMO3_HUMAN (29-146): 2.28e-12: 65.5: 29.51		HMBX1_HUMAN (3-339): 1.48e-64: 214: 26.08
+	Hs
		823411 PAXI_HUMAN (2-208): 2.41e-31: 125: 15.79		ISX_HUMAN (193-376): 1.88e-32: 124: 18.48
+	Hs
		727575 LHX4_HUMAN (3-81): 1.14e-10: 63.8: 22.89		HNF1B_HUMAN (7-421): 3.26e-50: 179: 17.98
+	Hs
		1255791 LHX3_HUMAN (3-81): 2.49e-09: 60: 20.48		LMX1A_HUMAN (121-423): 7.2e-31: 124: 11.22